摘要
目的:探索补肾益心汤对自发性高血压大鼠血管内皮功能障碍的干预作用。方法:选取健康自发性高血压大鼠40只,随机分为空白对照组及补肾益心汤大、中、小剂量组,每组10只动物,各组均喂饲基本饲料,补肾益心汤组大、中、小剂量组在喂饲基本饲料的基础上,每日加喂补肾益心汤15mL、10mL、5mL,分别于实验开始前及8周末测定血中一氧化氮(NO)及内皮素(ET)。结果:实验后药物组组内前后比较,NO显著升高,血压、ET水平显著降低,大剂量组变化更为显著,差异有统计学意义(P<0.05)。结论:补肾益心汤能够显著提高自发性高血压大鼠血管内皮因子NO水平,而降低ET水平,从而改善血管内皮功能。
Objective：To investigate the effect of the Bushenyixin decoction on the vascular endothelial dysfunction in spontaneously hypertensive rats（SHR）.Methods：A total of 40 rats with spontaneously hypertension were randomly divided into the blank control group,large,medium,and small dose Bushenyixin decoction group,with 10 rats in each group and each group was fed with basic feed.The large,medium,small dose Bushenyixin decoction groups were fed with the BushenYixin Tang 15ml,10ml,and 5ml addition to the basic feed daily.Blood nitric oxide（NO） and endothelin（ET） were measured before the experiment and on the 8th weekend after the start of the experiment.Results：The NO of the experiment groups was significantly increased after the experiment,and the blood pressure and ET level were significantly decreased.Changes in the large dose group was most significant.Conclusion：Bushenyixin decoction can significantly improve the NO level of vascular endothelial growth factor,reduce the level of ET in spontaneously hypertensive rats,so as to improve the function of vascular endothelium.
出处
《世界中医药》
CAS
2013年第8期939-941,共3页
World Chinese Medicine
基金
2012年度中山市第二批科技计划项目(医疗卫生)资助项目(编号:20122A083)
关键词
自发性高血压大鼠
补肾益心汤
一氧化氮
内皮素
Spontaneously hypertensive rats
Bushenyixin Decoction
Nitric oxide
Endothelin
作者简介
通信作者：吕波，硕士研究生，研究方向：中医药防治心血管病研究，E—mail：363405892@qq．com
