摘要
目的探讨急性冠脉综合征(ACS)患者糖化血红蛋白水平情况及其对ACS患者预后的影响。方法将102例急性冠脉综合征患者根据糖化血红蛋白水平分为糖化血红蛋白正常组(A组)(HbA1c<6.5%,n=31例)、糖化血红蛋白低危组(B组)(6.5%<HbA1c<7.5%,n=36例)、糖化血红蛋白高危组(C组)(HbA1c>7.5%,n=35例)3组,分别观察各组入院时、3个月后12个月后的极低密度脂蛋白(VLDL)、C反应蛋白(CRP)、体重指数(BMI)、射血分数(EF)及相关心血管不良事件,如心绞痛、严重心律失常、再发心肌梗死、肺部感染等并发症发生情况。结果①A、B组及C组患者入院时VLDL、CRP、BMI及EF值差异无统计学意义(P>0.05),而3个月后及12个月后C组EF值较入院时未明显改善(P>0.05);②住院及随访12个月期间C组心血管不良事件心绞痛发生率、肺部感染发生率及死亡率较入院时明显增高(P<0.05)。且HbA1c与心绞痛、严重心律失常、再发心肌梗死、肺部感染及死亡均呈正相关(r=0.412、0.271、0.319、0.251、0.134)。结论糖化血红蛋白异常可不同程度地升高急性冠脉综合征患者心血管不良事件的发生率。
Objective To investigate the effect of acute coronary syndrome patients with glycated hemoglobin level and its effecl on the prognosis of patk^ots with ACS. Methods 102 cases of patients with acute coronary syndrome accord- ing to the levels of glycosylated hemoglobin Ale were divided into normal group （group A） （HbAlc〈6.5%,n=31）, glycosyl,ated hemoglobirt in low risk group （group B） （6.5%〈HbAlc〈7.5%,n=36 cases）, glycosylated hemoglobin group （group C） （HbAlc〉7.5% high-risk group,n=35 group） three cases.Low density lipoprotein,C reactive protein （CRP）, body mass index （BMI）,EF value and related adverse cardiac events such as angina,arrhythmia,myoeardial infarction, recurrent pulmonary infection and other complications were observed after admission,after 3,12months. Results ① VLDL, CRP,BMI and EF values had no significant difference among group A,B,C after admintion （P〉0. 05）.The level of EF wasn＇t obviously improved after 3 months and 12 months （P〉0.05）; ②The incidence of pulmonary infection inci- dence rate and mortality of groups C were significantly higher than admintion during hospitalization and after 12 months of follow-up （P〈0.05）.And HbAlc with angina pectoris,arrhythmia,acute myocardial infarction,pulmonary in- fection and death were positively correlated （r=0.412,0.271,0.319,0.251 0.134）. Conclusion The abnormal glyeosylated hemoglobin increased cardiovascular adverse event rates in patients with acute coronary syndrome.
出处
《中国当代医药》
2013年第25期30-31,33,共3页
China Modern Medicine
