摘要
目的:探讨首次发病的强迫症(OCD)患者认知功能的特点及相关影响因素。方法:采用逻辑记忆、视觉再生记忆、连线测验、数字广度、Stroop测验及威斯康星卡片分类测验分别对35例首次发病的OCD患者(OCD组)及30名健康对照者(HC组)进行神经心理学测评;应用Yale-Brown强迫量表(Y-BOCS)、抑郁自评量表(SDS)、状态-特质焦虑问卷(STAI)评定患者的病情及抑郁、焦虑程度。结果:OCD组的逻辑延迟记忆、视觉再生记忆、连线测验A、B时间、数字广度倒背、Stroop测验字色阅读时间、威斯康星卡片分类测验成绩较明显差于健康对照组(P均<0.05)。OCD患者的病程与其视觉延迟记忆、数字广度倒背分呈负相关(r=-0.39,P=0.024;r=-0.38,P=0.027),SDS分与Stroop测验字色阅读时间正相关(r=0.37,P<0.05),Y-BOCS分、SAI分及TAI分与各神经心理学指标的相关性无统计学意义(P均>0.05)。结论:首次发病的OCD患者存在记忆、注意和执行功能损害。
Objective：To investigate the cognitive function features and related factors in first-episode patients with obsessive-compulsive disorder （OCD）.Method：Neuropsychological measuring including logical memory,visual reproduction memory,trail-making test,digit span,Stroop test and Wisconsin card sorting test were preformed in 35 first-episode OCD patients （OCD group） and 30 healthy collators （HC group）.The severity of disease,depressive and anxiety symptoms in OCD patients were assessed by Yale-Brown obsessive compulsive scale （Y-BOCS）,self-rating depression scale （SDS） and state-trait anxiety inventory （STAI）.Results：The achievements of logical delayed memory,visual reproduction memory,trail making test A and B,digit backward span,Stroop test and Wisconsin card sorting test in OCD group were significantly lower than those in HC group （all P0.05）.The course of OCD patient was negative correlated with visual delayed memory and digit backward span scores （r=-0.39,P=0.024;r=-0.38,P=0.027）,SDS score was positive correlated with the Stroop test color-word time （r=0.37,P0.05）,the results of the neuropsychological tests had no significant correlation with the scores of Y-BOCS,SDS,SAI and TAI（all P0.05）.Conclusion：Memory,attention and executive function in first-episode OCD patients are impaired.
出处
《临床精神医学杂志》
2013年第4期241-244,共4页
Journal of Clinical Psychiatry
关键词
强迫症
认知功能
神经心理学
obsessive-compulsive disorder
cognitive function
neuropsychology
作者简介
通讯作者：兰光华，E-Mail：languanghua@yahoo．com．cn
