摘要
介绍一种合成环丙羧酸的新工艺。以固体光气为原料,与2,4-二氯氟苯反应制得2,4-二氯-5-氟苯甲酰氯,然后与3-乙氧基丙烯酸乙酯偶联,后经环丙胺置换、在DMF中环合、水解制得环丙羧酸,总收率为39.1%。该工艺流程缩短、操作简单,环境污染小,值得进一步研究和推广。
New process for preparing cycloprophyl carboxylic acid was described. The target was prepared from 2,4 - Dichloro- 1 -fluorobenzene, which reacted with ethyl 3 -ethoxyacrylate, amination with cyclopropylamine, cyclization under DMF and hydrolysis. The total yield was 39. 1%. The process had many advantages, such as simple operation and less environmental pollution. In line with the green chemistry development direction, it deserved further research and popularization.
出处
《广州化工》
CAS
2013年第15期101-102,131,共3页
GuangZhou Chemical Industry
作者简介
作者简介：吕伟（1972-），男，工程师，主要从事药物合成及药物分析方面的研究。
通讯作者：杨朱红（1978-），男，工程师，主要从事药物合成及药物分析方面的研究。
