摘要
目的观察益气养阴活血法对糖尿病模型大鼠单核细胞趋化因子(MCP-I)及血浆纤溶酶原激活物抑制剂(PAI-1)的影响。方法取大鼠55只,分为5组,除健康对照组外,其余组给予高脂饲料,按30 mg/kg给大鼠腹腔单次注射STZ溶液1次,造模成功后除模型组和健康对照组外,各组连续灌胃药物4周,取血测定血糖血脂及MCP-I及PAI-1。结果给予丹蛭降糖胶囊灌胃后,血清MCP-I明显降低,与模型组比较差异有统计学意义(P<0.01),丹蛭高剂量组疗效优于吡格列酮组(P<0.05)。丹蛭高、低剂量组的PAI-1水平与模型组比较差异有统计学意义(P<0.05),但减低幅度不及吡格列酮组。结论具有益气养阴活血作用的丹蛭降糖胶囊能够调节血MCP-I及PAI-1高表达。
Objective To investigate the effect of the tonifying Qi,nourishing Yin on serum MCP-1 and PAI1 level,in the diabetic mouse model.Methods We picked out 55 mice,and divided them into 5 groups.All the treatment groups,were fed with high-fat diet and injected with STZ at 30mg / kg for one time.The herb was given to the groups except the control group for 4 weeks.Finally,we assessed the changes in blood glucose and lipid levels,MCP1 and PAI-1 content in the mice.Results The serum MCP-1 level in the medication group reduced obviously after being treated by the Capsule of Danzhi Jiangtang（P 0.01）.The PAI-1 level of the group treated by high Danzhi at a low dose decreases greatly compared to the model group（P 0.05）.Conclusion The capsule of Danzhi Jiangtang can inhibit the high expression of MCP-1 and PAI-1 in diabetic mouse models.
出处
《中国临床保健杂志》
CAS
2013年第4期397-399,共3页
Chinese Journal of Clinical Healthcare
基金
国家中医管理局项目[国中医药科技发(2012)39号]
作者简介
李中南，主任医师，硕士生导师，Email：LZN5151307@sohu．com
