摘要
目的:探讨血清甘油三酯(TG)、总胆固醇(TC)水平对原发性高血压病预后的作用。方法:选择我院就诊确诊为原发性高血压病例320例,所有病例随访3年,根据TG、TC水平分为正常组、临界组和升高组。随访前后行动态心电图(Holter),颈动脉内膜中膜厚度检查,观察所有患者3年的血压变化情况和颈动脉厚度变化情况及心脑血管事件发生率。结果:患者的TG、TC在三年前后均有不同程度的上升,除了TC正常组和临界组上升无统计学差异外,其他各组三年后均较三年前升高,差异有统计学意义,TG/TC升高组的三年后SDNN要低于TG/TC正常组,TG/TC升高组组内比较发现SDNN也要低于3年前,两组SBP、DBP均不同程度上升,但是患者3年后TG/TC升高组平均SBP、DBP均要高于TG/TC正常组,TG/TC升高组患者三年后的IMT也要厚于TG/TC正常组,且TG/TC升高组三年后的IMT要厚于三年前,而在TG/TC正常组二者间差异无统计学意义;两组HR差异无统计学意义。两组患无症状心肌缺血、心绞痛、脑血管意外比较,差异具有统计学意义。结论:评估TG、TC水平可以从尚未发生心、脑血管并发症的原发性高血压患者中及早筛选出高心血管风险者,对高血压心血管并发症的预防有重要意义。
Objective：To explore the effect of surum TG,TC concentration on the prognisis of essential hypertension.Methods：A total of 320cases with essential hypertension in our hospital from Jun 2007to Jun 2009were selected all patients were followed up for 3years.Concentration of TG and TC were determined and them were divided into normal group,critical group and elevated group.Ambulatory electrocardiogram（Holter）and carotid intima-media thickness,blood pressure,carotid thickness and incidence of cardiovascular and cerebrovascular diseases were observed before and after the foloow-up.Results：TG,TC concentrations of all the patients were higher than those 3years ago.The significant difference was observed in all groups except TC normal group and TC critical group.SDNN of TG/TC elevate group was lower than the normal group after three years.In the TG/TC elevate group,SDNN was lower than that 3years ago.SBP and DBP of all patient increased to some degree,but SBP and DBP of TG/TC elevate group was lower than that of TG/TC normal group after 3years.IMT was also the same as blood pressure.The difference in incidence of asymptomatic myocardial ischemia,cerebrovascular accident and angina between the two group was significan.Conclusions：Assessment of the level of serum TG,TC in patients with essential hypertension can filter high cardiovascular risk patients from patients who has not yet occur cardiovascular and cerebrovascular complications.It has an important significance to the prevention of the cardiovascular complications of hypertension.
出处
《海南医学院学报》
CAS
2013年第9期1238-1241,1245,共5页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210783)~~
作者简介
王秀袖（1974-），女，本科，四川广元人，主管检验技师，电话：13518321875，电子信箱：wangxiuxiul974@163．com。
