摘要
探讨高密度脂蛋白胆固醇（HDL．C）在新疆地区不同民族人群高尿酸血症发生中的异质性。调查汉族、维吾尔族和哈萨克族人群，检测血尿酸及血脂等相关生化指标。维吾尔族、汉族的HDL—C均为对照组高于高尿酸组．而哈萨克族HDL—C为高尿酸组高于对照组，哈萨克族m尿酸水平最低；相关性分析发现哈萨克族尿酸与HDL．C呈负相关（P〈0．05）。HDL—C是心血管相关疾病较为公认的保护因子，在哈萨克族人群中血尿酸水平较低时，随尿酸的升高HDL—C也升高，当血尿酸水平高过一定标准（如高于本次分级SUA-4）时才对心血管疾病产生负面影响，提示应关注哈萨克族的特殊遗传性。
The heterogeneity of high-density lipoprotein-cholesterol （ HDL-C ） in hyperuricemia was analyzed in Uygur, Han, and Kazak ethnic groups in Xinjiang. A total of 2 396 subjects were surveyed. The HDL-C levels were significantly decreased in hyperuricemia group compared with control group in Han and Uygur, while the reverse occurred in Kazak. The serum uric acid （ SUA ） level in Kazak was the lowest. The SUA was negatively correlated with HDL-C in Kazak （ P 〈 0. 05 ）. HDL-C was a recognized protective factor for cardiovascular disease. With the lowered SUA level in the Kazak group, HDL-C level was increased. When SUA level was higher than a certain level （ such as the SUA-4 ） , there existed a negative impact on cardiovascular disease.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2013年第7期589-591,共3页
Chinese Journal of Endocrinology and Metabolism
基金
国家自然科学基金项目（30760221）
新疆维吾尔自治区高校科研计划项目（XJEDU2010S28）
新疆维吾尔自治区自然科学基金（200821148）
达能营养中心膳食营养研究与宣教基金项目（DIC2006-13）
作者简介
通信作者：姚华，Email：yaohua01@sina．COm
