摘要
目的：分析红花黄色素对股骨骨折患者围手术期间的炎症因子影响,探讨注射用红花黄色素改变股骨骨折炎症因子的可行性,为临床应用提供可靠的科学参考。方法：本次研究对象为2011年2月—2013年6月来我院接受治疗的股骨骨折患者共计66例,其中男性患者42例,女性患者22例。随机分为3组进行研究治疗,即A组22例,采用田七丸进行治疗,男16例,女6例,患者年龄结构为19~44岁,平均年龄（31.32±7.11）岁,骨折时间为1.5~24.4 h,平均（8.9±6.11）h;B组22例,采用可塞风联合田七丸进行治疗,男14例,女8例,患者年龄结构为21~42岁,平均年龄（30.89±6.52）岁,骨折时间为2.8~25.2 h,平均（11.24±6.89）h;C组22例,针对本组患者的治疗,在A组的基础上加用红花黄色素进行治疗,男14例,女8例,患者年龄结构为22~44岁,平均年龄（32.23±9.01）岁,骨折时间为4.3~28.8 h,平均（13.25±7.01）h。临床针对患者骨折治疗,采用股骨锁定钢板固定治疗22例,剩余44例均采用股骨带锁髓内钉进行固定治疗,介入治疗过程中同时加入药物治疗模式,针对A组患者药物治疗给予口服田七丸,每次5 g,2次/d;针对B组患者药物治疗给予口服田七丸,每次5 g,2次/d的同时,进行可塞风8 mg肌肉注射治疗,1次/d;针对C组患者的药物治疗,在使用口服田七丸,每次5 g,2次/d的同时采用红花黄色素100 mg与0.9%氯化钠注射液混合250~300 mL,对患者进行静脉滴注,1次/d。上述药物治疗模式全部在患者入院接受治疗次日开始进行,对3组患者的静脉血采样时间分别为手术前（2、7 d）及手术后（8~12 d）凌晨6：30分进行,针对患者血清中IL-6、TNF-α炎症促使细胞因子的含量采用免疫学度量法分别进行测定,对异阶段性的所得IL-6、TNF-α测量数据采用SPSS21.0软件进行统计学处理。结果：未进行药物治疗前（即患者入院第2天）,对比3组患者血液标本中的血清IL-6、TNF-α含量,无明显差异,没有统计学意义（P〉0.05）;对比3组加入药物治疗后（即入院第7天）,患者血液标本中的血清IL-6、TNF-α含量差异显著,具有统计学意义（P〈0.05）;对比入院第2天、第7天以及术后第7天患者血液标本中的血清IL-6、TNF-α含量,差异显著,具有统计学意义（P〈0.05,P〈0.01）;术后第7天及入院地7天患者血液标本中的血清IL-6、TNF-α含量对比,A组与C组差异明显（P〈0.01）,B组与C组差异显著（P〈0.05）。结论：针对临床股骨骨折患者围手术期间的炎症因子抑制与清除,采用注射用红花黄色素可起到良好的效果,有效控制患者围手术期并发症的发生几率,推荐临床使用。
Objective :To analyze the influence of Safflower Yellow Injection on inflammatory factors of femur fracture patients during the perioperative period,and to explore the feasibility of Safflower Yellow Injection changing the inflammatory factors of femur fracture to provide reliable scientific reference.Methods :The study subjects were a total of 66 cases of femoral fracture patients from February 2011 to June 2013 in our hospital.42 patients were males and female patients 22 cases.They were randomly divided into three treatment groups,namely A group of 22 cases :pseudo-ginseng pills for treatment,16 males and 6 females,age structure of patients ranged from 19 to 44 years old,mean age(31.32 ± 7.11)years old,fracture time was 1.5 ~ 24.4 h,average(8.9 ± 6.11)h;B group :22 cases,pseudo-ginseng pills and Xafon treatment,14 males and 8 females,age structure from 21 to 42 years old,mean age(30.89 ± 6.52) years old,fracture time was 2.8 ~ 25.2 h,average(11.24 ± 6.89)h;C group :22 cases,based on the treatment of group A,Safflower Yellow Injection was added.male 14 cases,females 8 cases,age structure from 22 to 44 years old,mean age(32.23 ± 9.01)years old,fracture time was 4.3 ~ 28.8 h,average(13.25 ± 7.01)h.For patients with fractures,femoral locking plate fixation was for 22 cases,and the remaining 44 cases were performed using femoral intramedullary nail fixation.The drug treatment was added during the interventional treatment.Group A received Tianqi pills orally,each time 5 g,2 times/d.Patients in group B received pseudo-ginseng pills orally,each time 5 g,2 times/d,at the same time Xafon 8 mg was for intramuscular injection,once a day.Patients of group C used pseudo-ginseng pills orally,each time 5 g,2 times/d,at the same time using Safflower Yellow Injection 100 mg with 0.9% sodium chloride injection mixing 250 ~ 300 mL,once a day.All these drugs treatments started from the second day of patients admitted to hospital.Venous blood sampling times were before surgery(2,7 d)and after surgery(8 ~ 12 d)at the early morning 6 :30.Serum levels of IL-6 and TNF-α were tested by immunological measurement method.The results data of different stages were analyzed by using SPSS21.0 software.Result :Before drug treatment(the second day of patients admission),the serum IL-6,TNF-α levels in three groups had no significant difference(P>0.05).After drug treatment group(7 days after admission),the serum IL-6,TNF-α levels were varied significantly,with statistical significance(P<0.05).Serum IL-6,TNF-α levels on 2 days after admission,the first 7 days and 7 days after treatment in three groups had statistical significance(P<0.05,P<0.01).Postoperative day 7 and seven days after admission,serum IL-6,TNF-α contents in A group and C group were significantly different(P<0.01),in B group and C group were also significant(P<0.05).Conclusions :Safflower Yellow Injection can play a good effect on inhibiting and eliminating inflammatory cytokines of patients undergoing hip fracture surgery,and effectively control perioperative complications.It is recommended for clinical use.
出处
《辽宁中医药大学学报》
CAS
2013年第8期201-203,共3页
Journal of Liaoning University of Traditional Chinese Medicine
关键词
红花黄色素
活血祛瘀
股骨骨折
围手术期
中药治疗
炎症因子
影响
safflower yellow
activating blood stasis
femoral fractures
perioperative period
Chinese medicine treatment
inflammatory factors
influence
作者简介
胡波（1974-），男，四川广安人，主治医师，学士，研究方向：骨科学。
