摘要
目的探讨强直性脊柱炎流行病学情况及遗传方式，为优生优育和该病的防治和提供理论依据。方法分别选取山东省沿海，山东中部及西部地区三个地点，对强直性脊柱炎患病情况进行调查，患病组80例患者的家庭成员一、二、三级亲属患病人数分别是17、5、3例，通过Falconer回归法和Li—Mantel．Cart法分别估计强直性脊柱炎遗传度和分离比。结果强直性脊柱炎一级亲属患病率为7．23％，遗传度为85．94％，二级亲属患病率为0．94％，遗传度为57．4％，三级亲属患病率为0．39％，遗传度为36．2％，一、二、三级亲属平均加权遗传度为68．47％±1．64％。分离比为0．0889，说明强直性脊柱炎遗传方式为多基因遗传。结论强直性脊柱炎为多基因遗传病，遗传度是68．47％±1．64％，分离比是0．0889。通过该研究可以估计AS家系子代的发病风险，从而加强保护因素，降低该病的发病率，为优生学提供依据。
Objective To investigate the epidemiological situation and the mode of inheritance of anky- losing spondylitis （AS）. Methods The AS prevalence investigation was carded out from three different areas in Shandong Province to investigate the incidence of the 80 patients＇ family members of sick group and calculate the heritability of AS. Results After the investigation and calculation we found the incidence of primary rela- fives was 7.23% ,the heritability was 85.94% ,the incidence of secondary relatives was 0. 94% and the herita- bility was 57.4%, the incidence of thirdly relatives was 0. 39%, the heritability is 36. 2%, the average heritabili- ty among primary, secondary and thirdly was 68.47% ± 1.64%. Separation ratio was 0. 088 9. Conclusion AS is a polygenic disease,its average heritability was 68.47%± 1.64% and separation ratio is 0. 088 9. By this re- search, the incidence risk of AS patients＇ pedigree offspring can be assessed, then strengthen protective factors to reduce the incidence of the disease to provide the basis for eugenics.
出处
《国际儿科学杂志》
2013年第4期413-415,共3页
International Journal of Pediatrics
基金
基金项目：山东省教育厅资助经费项目（10LF22）
作者简介
通信作者：刘长云，Email：changyunl@163．com
