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食管癌肿瘤标记物miRNA的研究进展 被引量:5

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摘要 肿瘤标记物是肿瘤在生长过程中产生和释放某些特定类型的化学物质,可以通过检测其含量来判断肿瘤的存在以及其生长情况,并以此作为诊断标准,疗效评估以及预后判定。肿瘤标记物存在形式有多种,可分为肿瘤细胞分泌物以及肿瘤细胞表达物。microRNA(miRNA)是一类长度约为17~25个核苷酸的非编码单链核糖核酸分子。miRNA在动物体内通过转录后调剂方式作用于靶基因,参与细胞的增殖、分化、代谢、凋亡等过程。
出处 《中国老年学杂志》 CAS CSCD 北大核心 2013年第13期3270-3272,共3页 Chinese Journal of Gerontology
作者简介 杨志平(1969-),女,博士,副主任医师,主要从事消化道肿瘤基础及临床研究。 通讯作者:盛望(1968-),男,教授,博士生导师,主要从事肿瘤、抗病毒药物及疫苗的研究。
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  • 1Lawrie CH, Gal S, Dunlop HM, et al. Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B- cell lymphoma [ J ]. J Haema-tol, 2008 , 141 ( 5 ) : 672-5.
  • 2Schoppmann SF, Asari R, Riegler M. Barrett's esophagus 's a marker for increased risk for esophageal cancer and cardiorespiratory disease [ J ]. Endoscopy, 2013 ,45(2) :152-2.
  • 3Leidner RS, Ravi L, Leahy P,et al. The microRNAs, MiR-31 and MiR- 375, as candidate markers in Barrett's esophageal carcinogenesis [J]. Genes Chrom Cancer, 2012 ,51 (5) :473-9.
  • 4Fassan M, Volinia S, Palatini J,et al. MieroRNA expression profiling in human Barrett's carcinogenesis[ J ]. Int J Cancer,2011 , 129 (7) : 1661- 70.
  • 5Wijnhoven BPL, Hussey DJ, Watson DI, et al. MicroRNA profiling of Barrett's esophagus and esophageal adenocarcinoma [J]. Br J Surg, 2010,97(6) :853-61.
  • 6Kimura S, Naganuma S, Susuki D, et al. Expression of microRNAs in squamous cell carcinoma of human head and neck and the esophagus: miR-205 and miR-21 are specific markers for HNSCC and ESCC [J]. Oncol Rep, 2010,23(6) :1625-33.
  • 7Bartel DP. MicroRNAs : genomics, biogenesis, mechanism, and function [J]. Cell, 2004,116:281-97.
  • 8Hobert O. Gene regulation by transcription factors and microRNAs [J]. Science, 2008 ,319(5871 ) : 1785-6.
  • 9Calin GA, Sevignani C, Dumitru CD,et al. Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers [ J]. Proc Natl Acad Sci U S A, 2004,101 (9):2999-3004.
  • 10Mathe EA, Nguyen GH, Bowman ED, et al. MicroRNA expression in squamous cell carcinoma and adenocarcinoma of the esophagus:associa- tions with survival[ J ]. Clin Cancer Res, 2009 , 15 ( 19 ) :6192-200.

同被引文献33

  • 1邱卫黎,李澄婷,杨郁素,陈锡文.汕头地区恶性肿瘤住院病例的疾病构成及病死率分析[J].中华肿瘤防治杂志,2006,13(9):645-647. 被引量:5
  • 2乔蕾,孙玉凤.CEA等肿瘤标记物在消化道恶性肿瘤患者转归中漂移的研究[J].卫生职业教育,2007,25(13):138-141. 被引量:1
  • 3Liu Y,Daley S,Evdokimova VN,et al.Hierarchy of alpha fetoprotein (AFP)-specific T cell responses in subjects with AFP-positive hepatocellular cancer[J].J Immunol,2006,177 (1):712-721.
  • 4Schacherer D,Schoelmerich J,Zuber-Jerger I.The diagnostic approach to hepatocellular carcinoma[J].Z Gastroenterol,2007,45(10):1067-1074.
  • 5Gasper MJ,Diez M,Rodriguez A,et al.Clinical value of CEA and CA125 regardingrelapse and metastasis in resectable non-small cell lung cancer[J].Anticancer Res,2003,23(4):3427-3432.
  • 6Jung M,Jeung HC,Lee SS,et al.The clinical significance of ascitic fluid CEA in advanced gastric cancer with ascites[J].J Cancer Res Clin Oncol,2010,136(4):517-526.
  • 7Voliuia S,Calin GA,Liu CG,et al.A microRNA expression signature of human solid tumors defines cancer gene targets[J].Proc Nail Acad Sci USA,2006,103(7):2257-2261.
  • 8Yang M,Shen H,Qin C,et al.High expression of miR-21 and miR-155 predicts recurrence and unfavourable survival in non-small cell lung cancer[J].Eur J Cancer,2013,49(3):604-615.
  • 9李岩.胃癌肿瘤标志物及临床意义[J].实用医院临床杂志,2011,8(1):11-15. 被引量:54
  • 10张毅,李京玉,廖永晖,窦科峰.血清miRNA:一种新的疾病检测标记物[J].中华实验外科杂志,2011,28(3):479-480. 被引量:14

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