摘要
目的:研究秦艽醇提取物的抗炎及镇痛作用。方法:采用二甲苯致小鼠耳廓肿胀,角叉菜胶致大鼠足趾肿胀及冰醋酸致小鼠扭体反应,观察秦艽醇提物的抗炎及镇痛作用。结果:秦艽醇提物能降低二甲苯炎症模型小鼠的耳廓肿胀度(P<0.01),对角叉菜胶模型大鼠的急性炎症有一定的抑制作用,从第3小时起足趾容积和肿胀度与模型组比较具有统计学意义(P<0.05),秦艽醇提物还能提高小鼠的痛阈,减少冰醋酸致小鼠扭体次数,与模型组比较具有统计学意义(P<0.05)。结论:秦艽醇提物对二甲苯及角叉菜胶所致的炎症具有一定的抑制作用,同时具有明显的镇痛作用。
Objective： To study anti-inflammatory and analgesic effects of ethanolic extract of QinJioo （radix gentianae macrophyllae）. Method： Anti-inflammation and analgesic effects of ethanolic extract of QinJiao were observed with the methods of xylene-induced auricular edema of mice, carrageenin-induced toe swollen of rat and writhing response of mice induced by acetic acid. Result： Ethanolic extract of QinJiao could relieve auricular edema of xylene inflammation mice model （P〈0.01）, inhibit acute inflammation of carrageenin rat model, it had statistical meaning in toe volume and swelling degrees from the 3rd hour compared with the model group （P〈0.05）, ethanolic extract of QinJiao could improve pain threshold in mice and decrease the torsion times of mice, it presented statistical meaning compared with the model group （P〈0.05）. Conclusion： Ethanolic extract of QinJiao could inhibit the inflammation induced by dimethyl benzene and carrageenin, at the same time, it shows notable analgesic effects.
出处
《西部中医药》
2013年第7期28-30,共3页
Western Journal of Traditional Chinese Medicine
关键词
秦艽醇提取物
抗炎
镇痛
ethanolic extract of QinJiao （radix gentianae macrophyllae）
anti-inflammation
analgesic effects
作者简介
林清（1983-），女，硕士学位，助教。研究方向：中药基本理论与临床应用。
