摘要
目的观察在慢性阻塞性肺疾病急性加重(acute exacerbations of chronic obstructive airway disease,AECO-PD)患者中应用他汀类药物对血清C反应蛋白(CRP)和白介素-8(IL-8)及肺功能的影响。方法将62例AECO-PD患者随机分成治疗组32例,对照组30例。两组均给予常规治疗,治疗组在常规治疗基础上加服他汀类药物(瑞舒伐他汀钙)。比较两组治疗前后血清中C反应蛋白和白介素-8及肺功能的改善情况。结果治疗组治疗前后血清CRP和IL-8水平差值显著大于对照组(P<0.05);肺功能:治疗组第一秒用力呼气容积占预计值百分比(FEV1%)和第一秒用力呼气容积占用力肺活量百分比(FEV1/FVC)的差值显著大于对照组(P<0.01)。结论他汀类药物对慢性阻塞性肺疾病急性加重患者具有抗炎、减轻炎症反应,改善肺功能,促进疾病恢复的功能。
Objective： To investigate the effect of sratin on concentrations of serum CRP,interleukin-8（IL-8） and pulmonary function in patiens with acute exacerbations of chronic obstructive airway disease（AECOPD）.Methods： Sixty-two hospitalized patients with AECOPD were randomly divided two groups,the treatment group（32 cases）,and the controlled（30 cases）.The treatment group received the additional statin.The changes of the levels of serum CRP,IL-8 and the pulmonary function were observed after the treatment and were compared.Results： The difference of value of serum CRP,IL8 and FEV1%,FEV1 / FVC in the treatment group was significantly higher than that in the controls（P 0.05）.Conclusion： Station can play the role of anti-inflammation,relieve inflammatory reaction and improve pulmonary function in patients with AECOPD.
出处
《泰山医学院学报》
CAS
2013年第4期264-266,共3页
Journal of Taishan Medical College
作者简介
陈燕（1976-），女，山东泰安人，主治医师，本科，主要从事呼吸内科临床工作。
