摘要
[目的]观察合欢花治疗抑郁症疗效。[方法]使用多中心随机平行对照方法,将100例住院及门诊患者按随机数字表方法随机分为两组。治疗组50例使用合欢花汤剂(合欢花30g,1剂/d,水煎取汁200mL,上、下午各1次口服)。对照组50例盐酸文拉法新缓释片(起始剂量为37.5mg/d,晚进餐时单次服用,根据病情和耐受性逐渐增加剂量至225mg/d)。连续治疗6周为1疗程。观测临床疗效、认知功能及生化指标。连续治疗1疗程(42d)判定疗效。[结果]治疗组痊愈8例,显效20例,有效10例,无效12例,总有效率76.00%。对照组痊愈10例,显效20例,有效10例,无效10例,总有效率80.00%。两组无显著差异(P>0.05)。治疗组认知功能改善优于对照组(P<0.05)。血浆5-HT、NE、DA水平两组均呈上升趋势(P<0.05,P<0.01),组间无明显差异(P>0.05)。不良反应对照组6例,治疗组2例,未特殊治疗缓解,未影响继续观察。[结论]合欢花汤剂与盐酸文拉法新缓释片治疗抑郁症具有等效性,改善认知功能优于盐酸文拉法新。
[Objective]To observe the effects of Albizia julibrissin flower（AJF） in patients with depression.[Methods]A randomized parallel controlled multicenter method was employed.Using a random number table,100 cases of depression patients were divided into the treatment group（50 cases） and control group（50 cases）.The treatment group was treated with AJF（Hehuanhua 30g,1 dose / d,decocted in water for 200mL,on the afternoon of the 1 times,oral）,and the control group with venlafaxine hydrochloride sustained-release tablets.Two groups were treated for 6 weeks for 1 course.Efficacy,cognitive function and biochemical criterion were detected.After 1 course of treatment the efficacy was determined.[Results]The treatment group 8 cases were cured,20 cases markedly effective,effective 10 cases,invalid 12 cases,the total efficiency of 76.00%.The control group cured 10 cases,markedly effective in 20 cases,effective 10 cases,invalid 10 cases,the total efficiency of 80.00%.There was no significant difference between two groups（P〈0.05）.6 cases with adverse reaction were in the control group,and 2 cases in the treatment group,and all cases were without special treatment,and didn＇t affect the observation.[Conclusion]Treating depression with AJF has a good effect like venlafaxine hydrochloride sustained-release tablets,and it was superior to venlafaxine hydrochloride sustained-release tablets treatment group in improving the cognitive function of depression patients.
出处
《实用中医内科杂志》
2013年第3期18-20,共3页
Journal of Practical Traditional Chinese Internal Medicine
基金
广西教育厅课题(No:201203YB111)
作者简介
通讯作者：张永全，E—mail：gxzyq@126．com Tel：13877127732
