摘要
Toll样受体（TLRs）是模式识别受体（PRRs）之一，其因胞外段与一种果蝇蛋白Toll同源而得名。TLRs广泛分布于巨噬细胞、树突样细胞、T细胞、B细胞等免疫细胞，还存在于一些组织细胞巾，如心肌细胞等。TLRs不仅可诱导固有免疫反应作为机体对病原微生物的第一道防线，也可通过激活抗原递呈细胞诱导适应性免疫反应。大量证据表明，TLRs除参与宿主抵抗病原菌的侵害之外，还在非感染性组织损伤中起作用，例如心肌缺血再灌注损伤，缺血后心肌重塑和动脉粥样硬化等疾病。故了解TLRs信号通路及其在心血管疾病中的作用可帮助我们确定干预心血管疾病的潜在靶点，且有重要的临床应用价值。
Toll like receptors （TLRs） , which are named after the extracellular domain homologous to a Drosophila protein Toll, belong to the family of pattern recognition receptors （PRRs）. TLRs widely express in macrophages, dendritic cells, T cells, B cells and other immune cells. They are also detected on many other tis- sue cells, for example myocardial cells. TLRs can not only trigger innate immune response as the body＇ s first line of defense against pathogenic microorganisms, but also induce adaptive immune response through the acti- vation of antigen presenting cells. In addition to participating in the host defense against infectious pathogens, accumulating evidence suggests that TLRs still play a role in the non-infectious tissue injury, such as myocardi- al ischemia and reperfusion injury, ischemic myocardial remodeling, atherosclerosis and other diseases. Thus, understanding TLRs signaling pathways and their role in cardiovascular diseases can help us to identify potential targets for the intervention cardiovascular diseases.
出处
《国际免疫学杂志》
CAS
2013年第4期253-255,259,共4页
International Journal of Immunology
基金
国家自然科学基金主任基金（81241006）
作者简介
通信作者：关秀茹，E-mail：guanxiuru0451@yahoo．com．cn
