摘要
目的探讨慢性乙型肝炎患者肝脏组织中环氧化酶-2(COX-2)的表达及其临床意义。方法选择正常对照组10例,慢性乙型肝炎轻、中、重型各10例,肝硬化患者10例作为本实验的研究对象,应用SABC法分别对肝组织标本中COX-2测定,并结合病情轻重进行综合分析。结果慢性乙型肝炎组和肝硬化组肝组织中COX-2阳性率均明显高于对照组(P=0.0001),慢性乙型肝炎各组肝组织中COX-2含量存在显著的差异(P=0.0001)。结论 COX-2在慢性乙型肝炎和肝硬化的病理发展过程中起着一定的作用。
Objective To study the significance and expression of cyclooxygenase-2（COX-2） in liver tissue in the patients with chronic hepatitis B. Methods The COX-2 protein was determined in liver tissue in 30 cases of chronic hepatitis B, 10 cases of liver cirrhosis, 10 control cases by SABC and the relationship between the expression of COX-2 and liver disease severity was analyzed. Results The expression of COX-2 in serum and liver tissue in chronic hepatitis B and liver cirrhosis group were increased and obviously higher than those in the controls （P = 0. 0001 ） , also increased with hepatic inflammation getting worse （P = 0. 0001 ）. Conclusion COX-2 could play a role in pathological process in chronic hepatitis B and liver cirrhosis.
出处
《胃肠病学和肝病学杂志》
CAS
2013年第6期535-537,共3页
Chinese Journal of Gastroenterology and Hepatology
基金
上海市闸北区科委重点课题(2007-重点-12)
关键词
环氧化酶-2
慢性乙型肝炎
肝硬化
肝组织
免疫组化
Cyclooxygenase-2 （ COX-2 ）
Chronic hepatitis B
Liver cirrhosis
Liver tissue
Immunohistochemical stain
作者简介
第一作者简介：浦裕美，副主任医师，硕士，研究方向：肝脏疾病的临床和基础。E-mail：puyumei88@163．com
