摘要
目的比较三种放射治疗技术治疗椎体转移瘤的剂量学差异,提高肿瘤椎体转移的治疗效益。方法选取10例恶性肿瘤椎体转移患者,应用三维治疗计划系统分别为每例患者设计三种治疗计划:常规放射治疗(CRT)、适形放射治疗(3D-CRT)和调强放射治疗(IMRT),评估和比较各计划靶区剂量分布及危及器官剂量学参数的差异,在保证靶区治疗剂量和重要器官耐受的基础上采用调强放射治疗,并观察治疗效果和不良反应。结果 IMRT和3D-CRT对比CRT能显著提高靶区的适形度(CI),3D-CRT较IMRT能明显提高靶区剂量的均匀性(HI),IMRT在保护心脏、脊髓、食管方面明显优于其他两种技术。10例患者通过调强放射治疗后止痛有效率达100%。结论在预期生存时间较长的恶性肿瘤椎体转移患者中,应用调强放射治疗能明显减少重要器官受照的最大剂量,可望提高生活质量。
Objective To compare the difference of the three modalities of radiotherapeutic technique for metastatic spinal lesions.Methods Ten patients with vertebral metastatic cancer were designed conventional radiation therapy（CRT） plan,3-Dimensional conformal radiation therapy（3DCRT） plan and intensity modulated radiation therapy（IMRT） plan through treatment planning system（TPS）.Evaluate the difference of dosimetric parameters between targetarea and criticalorgan.Then patients were treated with IMR.Results The coverage index（CI） of IMRT and 3DCRT plan were better than that of CRT plan.The relative dose homogeneity index（HI） of 3DCRT plan was better than that of the IMRT plan.The IMRT could better protect the heart,spine and esophagus than the others.The effective rate of relieving pain of ten patients was 100% by applying IMRT.Conclusions Utilizing intensity modulated radiation therapy in the expected long-term survival of patients diagnosed with vertebral metastatic can help us to reduce the maximum radiation dose of surrounding normal organs.
出处
《中国肿瘤临床与康复》
2013年第5期434-436,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
椎体转移瘤
放射治疗
三维适形放疗
调强放射治疗
Spinal metastatic Conventional radiotherapy Three-dimensional conformal radiotherapy Intensity modulated
作者简介
卢奕宇，男，主治医师，主要从事肿瘤专业。
