摘要
妊娠期母体维生素D水平及生物活性上调,同时钙吸收水平也较孕前增加。孕期母体维生素D缺乏会影响胎儿血钙浓度,从而影响胎儿骨骼骨化,影响胎儿骨密度和骨矿积累,甚至导致胎儿出生低体重风险增加。妊娠期母体维生素D水平对婴儿期、儿童期的体重增长和骨量及骨密度也有一定的影响。这种影响与母体维生素D受体基因多态性和子代维生素D受体基因及蛋白的表达有关。鉴于维生素D不足普遍存在,孕期妇女需补充维生素D,然而对维生素D的补充剂量目前尚未有统一意见。
Maternal vitamin D level and biological activity are up-regulated during pregnancy. Meanwhile, the absorption of calcium increases more than it does before. Maternal vitamin D deficiency can affect fetal serum calcium concentration, thus affecting skeletal ossification, bone mass, and bone mineral density of the fetal, and resulting in increased risks of low birth weight. Maternal vitamin D level during pregnancy also has certain influence on weight gain, bone mass, and bone mineral density during the infancy stage and childhood. This effect is related to maternal vitamin D receptor gene polymorphism and the expression of vitamin D receptor gene and protein in the offspring. As the lack of vitamin D is very common, the supplementation of vitamin D during pregnancy is very important. However, no agreement of the dose of vitamin D supplementation has been reached yet.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2013年第5期533-536,共4页
Chinese Journal of Osteoporosis
基金
无锡市科技局项目(CSE01017)
无锡市医院管理中心项目(YGZZ1107)
作者简介
通讯作者：肖建平，E-mail：jiangpingx999@126．com
