摘要
目的:探讨血浆表皮型脂肪酸结合蛋白(epidermal fatty acid binding protein,E-FABP)与脂肪酸合成酶(fatty acid syn-thase,FASN)蛋白水平与人股动脉粥样硬化(atherosclerosis,AS)及相关危险因素的关系。方法:对178例患者行股动脉彩超检查并测定股动脉内膜中层厚度(intimal medial thickness,IMT),根据股动脉IMT分为股AS组(128例)和对照组(50例),测定空腹血浆E-FABP、FASN蛋白水平,分析其与股AS及危险因素的关系。结果:与对照组比较,股AS患者血浆中E-FABP与FASN蛋白水平增高(P<0.05),血浆E-FABP与FASN水平呈正相关(P<0.05),血浆E-FABP水平与年龄、体质指数(body mass index,BMI)、甘油三酯(triglyceride,TG)、脂联素、C反应蛋白(C reactive protein,CRP)、IMT呈正相关(P<0.05),血浆FASN水平与年龄,BMI、空腹血糖(fasting blood-glucose,FPG)、稳态模型胰岛素抵抗指数(homeostasis model assessment-insulin resistance index,HOMA-IR)、TG、脂联素、CRP、IMT呈正相关(P<0.05),血浆E-FABP、FASN与高密度脂蛋白-胆固醇呈负相关(P<0.05);Logistic回归分析表明:年龄,FASN,E-FABP,HOMA-IR,CRP,TG是股AS的危险因素(P<0.05)。结论:股AS与血浆E-FABP、FASN水平相关联,可能成为新的诊断与评价人股AS的循环标志。
Objective ：To investigate the relationship of plasma protein levels of epidermal fatty acid binding protein（E-FABP） and fatty acid synthase（FASN） with risk factors of human femoral atherosclerosis. Methods ：One hundred and seventy-eight patients were detected by color Doppler with intimal-media thickness（IMT） measurement. Then,patients were divided into femoral atherosclerosis group（n=128） and control group（n=50） according to IMT. Fasting protein levels of E-FABP and FASN in plasma were detected and their relationship with femoral atherosclerotic risk factors was measured. Results：Plasma protein levels of E-FABP and FASN in atherosclerotic group were increased compared with those in control group（P〈0.05）. Correlation analysis showed that there was a pos- itive correlation between plasma levels of E-FABP and FASN （P〈0.05）. E-FABP level was correlated positively with age, body mass index （BMI）, triglyceride （TG）, adiponection, C reactive protein （CRP） and IMT （P〈0.05）. FASN level was correlated positively with age, BMI, fasting plasma glucose, homeostasis model assessment-insulin resistance （HOMA-IR）, TG, adiponectin, CRP and IMT （P〈 0.05）. Plasma levels of E-FABP and FASN were negatively correlated with high-density lipoprotein-cholesterol（P〈0.05）. Logistic re- gression analysis showed that age, FASN, E-FABP, HOMA-IR, CRP and TG were the risk factors of femoral atherosclerosis （P〈0.05）. Conclusions：Femoral atherosclerosis associated with plasma levels of E-FABP and FASN, which maybe a new circulating biomarker in diagnosis and evaluation of human femoral atherosclerosis.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2013年第5期551-554,共4页
Journal of Chongqing Medical University
关键词
股动脉粥样硬化
脂肪酸结合蛋白
脂肪酸合成酶
femoral atherosclerosis
epidermal fatty acid binding protein
fatty acid synthase
作者简介
陈斌．Email：chinachenbin000@163．com．研究方向：外周血管疾病的诊断与治疗。
通信作者：周志强，Email：qiang6364@sohu．com。
