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CYP2D6基因多态性与阿片类药物代谢的关系 被引量:1

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摘要 阿片类药物使用有明显的个体差异,这种机体对疼痛敏感性的差异反应,可能与基因水平调节阿片类药物的药代动力学(包括代谢酶活性、载体)和药效学(受体和信号转导)有关[1]。
出处 《临床麻醉学杂志》 CAS CSCD 北大核心 2013年第5期516-517,共2页 Journal of Clinical Anesthesiology
作者简介 通信作者:宋春雨,Email:13936130754@163.com
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  • 1Cohen M, Sadhasivam S, Vinks AA. Pharmacogenetics in perioperative medicine. Curt Opin Anaesthesiol, 2012, 25 (4) :419-427.
  • 2Borges S, Desta Z, Jin Y,et al. Composite functional genetic and comedication CYP2D6 activity score in predicting tamox- ifen drug exposure among breast cancer patients. J Clin Pharmacol, 2010,50 (4) : 450-458.
  • 3Sadhasivam S, Myer CM 3rd. Preventing opioid-related deaths in children undergoing surgery. Pain Med, 2012 13 (7) ,982-983.
  • 4Yuan R, Zhang X, Deng Q, et al. Impact of CYP3A4 1G polymorphism on metabolism of fentanyl in Chinese patients undergoing lower abdominal surgery. Clin Chim Acta,2011, 412(9-10) 755-760.
  • 5Gadeyne C, Van der Heyden S, Gasthuys F, et al. The in- fluence of modulation of P-glyeoprotein and/or cytochrome ]?450 3A on the pharmacokinetics and pharmacodynamics of orally ad ministered morphine in dogs. J Vet Pharmacol T- her, 2011,34(5) : 417-423.
  • 6Frost J, Helland A, Nordrum IS, et al. Investigation of mor- phine and morphine glucuronide levels and cytochrome P450 isoenzyme 2D6 genotype in codeine-related deaths. Forensic Sci Int, 2012,220(1-3) : 6-11.
  • 7Ltsch J, Rohrbacher M, Schmidt H, et al. Can extremely low or high morphine formation from codeine be predicted prior to therapy initiation? Pain, 2009,144(1-2) : 119-124.
  • 8Kirchheiner J, Schrnidt H, Tzvetkov M, et al. Pharmacoki- netics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication. Pharmacogenomics J,2007,7(4) :257-265.
  • 9Ciszkowski C, Madadi P, Phillips MS, et al. Codeine, ultra- rapid-metabolism genotype, and postoperative death. N Engl J Med,2009,361(8) :827-828.
  • 10李芹,王睿,郭雅,裴斐.中国人群细胞色素P4502D6基因多态性对曲马多药代动力学的影响[J].中国临床药理学杂志,2009,25(4):302-307. 被引量:10

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