摘要
目的观察盐酸氨溴索气管内滴入灌洗佐治新生儿胎粪吸入综合征(meconium aspiration syndrome,MAS)的临床效果。方法将入选的70例MAS患儿随机分为两组,对照组33例予常规综合疗法并采取支持性护理措施,观察组37例在此基础上加用盐酸氨溴索气管内滴入灌洗,每日1次,持续3d,观察治疗期间两组患儿血氧饱和度(SpO2)、机械通气时间等相关指标与临床疗效。结果治疗48h后,两组患儿SpO2均明显上升,且观察组患儿SpO2明显高于对照组(P<0.05),逐步接近正常值水平;观察组患儿治疗过程中吸痰次数显著少于对照组(P<0.01),机械辅助通气时间及住院时间均显著短于对照组(P<0.01)。治疗5d后,两组患儿症状均改善,观察组的总有效率显著高于对照组(P<0.05)。结论盐酸氨溴索气管内滴入灌洗佐治MAS能提高常规疗法的治疗效果。
Objective To observe the clinical efficacy of ambroxoI hydrochloride flushing via intratracheal in- stillation in assisted treatment of neonatal meconium aspiration syndrome（MAS）. Methods Relevant indicators inclu- ding SpO2 ,assisted ventilation time and the clinical effects of both groups were observed and compared. Results Af- ter treating for 48 hours, the SpO2 of both groups obviously increased. And the babies in the observation group had significantly higher SpO2 （ P 〈0.05）which gradually got close to the normal level. The frequency of sputum suction of the observation group was obviously less than that of the control group during the treatment（ P 〈0.01）. The assis- ted ventilation time and duration of hospitalization of the observation group were also shorter than those of the control group（ P 〈0.05 ）. After treating for 5 days,symptoms of both groups improved. The total effective rate of the obser- vation group was significantly higher than that of the control group（ P 〈0.05 ）. Conclusion Ambroxol hydrochloride flushing via intratracheal instillation in assisted treatment of MAS can improve the therapeutic effect of conventional treatment.
出处
《右江医学》
2013年第2期184-186,共3页
Chinese Youjiang Medical Journal
关键词
盐酸氨溴索
胎粪吸入综合征
新生儿
ambroxol hydrochloride
meconium aspiration syndrome neonates
作者简介
黄剑飞（1966-），男（壮族），广西武呜县人，主治医师，医学学士。研究方向：儿科危重症及新生儿营养。
