摘要
目的探讨D-二聚体(D-dimers,DD)和胱抑素C(Cys-c)与冠心病冠状动脉病变程度的相关性及其临床意义。方法依据冠脉造影检查确定入选对象120例,按病变血管数目分为正常组(12例)、单支组(26例)、双支组(46例)、三支组(36例),应用ELISA检测各组DD和Cys-c,同时分析和冠状动脉病变程度评分(Gensini)的关系。结果冠心病组DD和Cys-c水平较正常组明显增高(P<0.05),DD水平与Gensini法评分呈正相关(γ=0.748,P<0.05),Cys-C水平与Gensini法评分呈正相关(γ=0.627,P<0.05)。结论在冠心病发生、发展过程中DD和Cys-C发挥重要作用,而且其表达水平和冠状动脉病变程度密切相关。
【Objective】 To explore the relationship between severity of coronary artery lesions and plasma levels of D-dimers,cystatin-c.【Methods】120 cases were recruited in this study according to diagnostic coronary angiography,and divided into 4 groups.normal group（n = 12）,the number of diseased vessels,single vessel group（n=26）,double vessel group（n=46）,three groups（n = 36）,The expression of D-dimers and cystatin-c were evaluated by Enzyme link immuno sorbent assay（ELISA）,and analysis the relationship between severity of coronary artery lesions and plasma levels of D-dimers,cystatin-c.【Resluts】DD and Cys-c level of CHD group was significantly higher than the normal group（P ＆lt;0.05）.DD levels and Gensini method score was positively correlated（r = 0.748,P ＆lt;0.05）,Cys-C levels and Gensini method score was positively correlated（r = 0.627,P ＆lt;0.05）.【Conclusion】The DD and Cys-C play an important role in the development process of Coronary heart disease,and the expression levels and closely related to the severity of coronary lesions.
出处
《中国医学工程》
2013年第4期19-20,共2页
China Medical Engineering
