摘要
目的对比研究矿物药玄明粉与无水硫酸钠结构与药效差异,探索二者的作用机制。方法采用AXIOS型X射线荧光光谱法对二者结构进行比较;采用小鼠胃排空、肠推进模型和复方地芬诺酯所致便秘模型对二者药效进行比较。结果玄明粉有正交和立方两种晶型,无水硫酸钠只有正交晶型;除共有化学组成外,玄明粉还含有Al2O3、K2O、SrO、ZnO、Cl,无水硫酸钠仅有Fe2O3;药效对比实验中,发现二者对小肠运动的影响具有显著性差异(P<0.01)。结论玄明粉与无水硫酸钠在结构和药效上存在一定的差异,实验结果可为临床应用提供参考依据。
Objective To compare the differences between weathered sodium sulfate （WSS） and anhydrous sodium sulfate （ASS） from structure and part potency and to explore the mechanism of action. Methods AXIOS X-ray Fluorescence Spectrometer was applied to analyze structure. We selected the model of gastric emptying, intestinal propulsion, and Compound Diphenoxylate-induced constipation. Results The result showed that there were two crystal forms： orthogonality and cube in WSS, while only orthogonality in ASS; Meanwhile, after analyzing the microelement of the two by X-ray Fluorescence Spectrometer, we found out that the common materials, yet, in WSS there were more A1203, K20, SrO, ZnO, and CI-, while there was only Fe203 in ASS. When comparing the medicative function of the two, we found out that there was an obvious difference （P 〈 0.01）. Conclusion There are some differences in structure and medicative function, which could provide the reference basis for clinical application.
出处
《中草药》
CAS
CSCD
北大核心
2013年第8期982-984,共3页
Chinese Traditional and Herbal Drugs
基金
国家中医药管理局行业专项资助项目(201007011-08)
关键词
玄明粉
无水硫酸钠
结构
药效
晶型
weathered sodium sulfate
anhydrous sodium sulfate
structure
efficacy
crystal type
作者简介
游宇（1986-），女，助教，硕士研究生，研究方向为中药新制剂和新剂型的研究。Tel：13980590846E-mail：415416295@qq．com
通信作者傅超美（1961-），男，四川简阳人，教授，博士生导师，研究方向为中药新制剂和新剂型的研究。E—mail：chaomeifu@126．com
