摘要
目的探讨RegⅣ蛋白及糖尿病在胰腺癌发生、发展中的作用。方法免疫组化方法检测RegⅣ蛋白伴或不伴2型糖尿病在人胰腺癌组织中的表达情况，分析其与胰腺癌进展的关系。结果60例胰腺癌组织中，RegIV蛋白表达阳性率为71．7％，明显高于正常胰腺组织的30．0％（X^2=10．97，P〈0．05）；RegⅣ蛋白阳性胰腺癌患病率为87．8％明显高于阴性者的54．8％（OR=5．90，95％CI 1．90-17．89）。Spearman相关分析显示，胰腺癌中的RegⅣ蛋白表达与糖尿病呈正相关关系（rs=0．331，P〈0．05）；胰腺癌组织中RegⅣ过表达及合并糖尿病与胰腺癌TNM分期、组织学分化程度、肿瘤大小以及淋巴转移明显相关（P〈0．05），但与患者年龄、性别无关（P〉0．05）。结论RegⅣ蛋白在糖尿病合并胰腺癌患者中过表达，在胰腺癌的发生发展中起着重要作用，可能作为糖尿病及胰腺癌患者一个新的预澳十因子。
Objective To evaluate the RegⅣ protein expression profile in pancreatic cancer with or without diabetes, and to define the contribution of Reg Ⅳ in pancreatic cancer development. Methods The expressions of RegⅣ protein with or without type 2 diabetes in human pancreatic canc- er tissue was detected by immunohistochemistry, in order to analyze its relationship with pancreatic cancer progression. Results The positive expression rate of RegIV in 60 patients with pancreatic canc- er was 71.7 % （43/60）. The positive expression rate of pancreatic cancer tissue was significantly high- er than normal pancreatic tissue （30.0%,X^2=10.97, P〈0.05）. The prevalence of RegⅣ protein- positive pancreatic cancer 87.8% （43/49） was significantly higher than the negative pancreatic cancer 54.8% （17/31） （OR=5.90, 95%CI 1.90-17.89）. Analysis using the Spearman correlation, overex- pression of RegIV protein in pancreatic cancer resulted in accelerated diabetes （rs=0. 331 ,P〈0.05）. Overexpression of RegⅣ protein in pancreatic cancer and with diabetes were significantly correlated with TNM stage, tumor size, lymph node metastasis and degree of differentiation on histology, but not with age and gender. Conclusions RegⅣ protein overexpresses in pancreatic cancer patients with diabetes and plays an important role in the development of pancreatic cancer. It may be used as a pre- dictor for patients with diabetes and pancreatic cancer.
出处
《中华肝胆外科杂志》
CAS
CSCD
北大核心
2013年第4期271-274,共4页
Chinese Journal of Hepatobiliary Surgery
基金
开封市科技局发展计划项目（100362）
关键词
胰腺肿瘤
糖尿病
2型
免疫组织化学
Pancreatic neoplasms
Diabetes mellitus,type 2
Immunohistochemistry
作者简介
通信作者：庞妩燕，电子信箱：PWY5694@163．com
