摘要
目的探讨普罗布考能否降低老年不稳定型心绞痛患者对比剂肾病(CIN)的发生率。方法将拟行经皮冠状动脉介入术(PCI)治疗的163例老年不稳定型心绞痛患者随机分为基础治疗组(n=81)和普罗布考组(n=82)。普罗布考组在常规治疗基础上加服普罗布考,术前3d至术后3d口服250mg,3次/天。所有患者术前及术后连续3d检测血清肌酐(Scr)水平,术前及术后24h检测尿中性粒细胞明胶酶相关性脂蛋白(NGAL)、尿白细胞介素-18(IL-18)、肾损伤分子-1(KIM-1)水平,并比较两组患者CIN的发生率。结果两组共发生CIN 15例(9.20%),其中基础治疗组12例(14.81%),普罗布考组3例(3.66%),两组CIN的发病率差异有统计学意义(P<0.05)。结论对不稳定型心绞痛接受PCI治疗的老年患者预防性应用普罗布考可以有效预防CIN的发生。
Objective To study the prevention effects of probucol on contrast-induced nephropathy（CIN） in elder patients with unstable angina pectoris（UAP）.Methods 163 elder inpatients with UAP were randomly divided into two groups,the basic treatment group（n=81） and the probucol treatment group（n=82）.On the base of conventional therapy,the probucol treatment group was given oral probucol 250 mg,3 times daily from preoperative 3 d to postoperative 3 d in angioplasty.The values of serum creatinine（Scr）,urine NGAL,IL-18 and KIM-1 were detected before angioplasty and for continuous 3 d after angioplasty in the two groups.Then the incidence rates of CIN were compared between the two groups.Results CIN occurred in 15 cases（9.20%）,12 cases（14.81%） in the basic treatment group and 3 cases（3.66%） in the probucol treatment group,the incidence rats showing statistical difference between the two groups（P0.05）.Conclusion Prophylactic treatment with probucol in elder patients with UAP undergoing coronary angiography or intervention has a preventive role against CIN.
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第14期1593-1594,1597,共3页
Chongqing medicine
作者简介
赵凯（1980～），主治医师，硕士研究生，主要从事冠心病、高血压等心血管疾病的临床研究。
