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丙型肝炎病毒感染与中枢神经系统损害 被引量：2

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摘要 全世界已有超过1．7亿人受到丙型肝炎病毒（hepatitis Cvirus，HCV）感染。因此，HCV感染已成为全球性公共卫生问题。HCV主要通过输血，使用血液制品，注射，接触污染的血液等途径传播。随着许多国家对血液及血液制品进行HCV筛查，经临床输血和血液制品传播的风险已大大降低，
作者 桑明 邓莉平 吴建国 霍文哲
机构地区 武汉大学动物实验中心/ABSL- 中南医院感染科 病毒学国家重点实验室
出处 《中华实验和临床病毒学杂志》 CAS CSCD 2013年第2期153-155,共3页 Chinese Journal of Experimental and Clinical Virology
基金 艾滋病和病毒性肝炎等重大传染病防治科技重大专项（2009ZX10004-403） 国家自然科学基金项目（81271334）
关键词 丙型肝炎病毒感染 中枢神经系统损害 HCV感染 血液制品 公共卫生问题 临床输血 接触污染 传播
分类号 R51 [医药卫生—内科学]
作者简介 通信作者：霍文哲，Email：wenzheho@whu．edu．cn，电话：（＋86）27－68759807
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参考文献38

  • 1Radkowski M, Wilkinson J, Nowicki M, et al. Search for hepatitis C virus negative-strand RNA sequences and analysis of viral sequences in the central nervous system: evidence of replication. J Virol, 2002, 76:600-608.
  • 2Letendre S, Paulino AD, Rockenstein E, et al. Pathogenesis of hepatitis C virus coinfection in the brains of patients infected with HIV. J Infect Dis, 2007, 196:361-370.
  • 3Wilkinson J, Radkowski M, Laskus T. Hepatitis C virus neuroinvasion: identification of infected cells. J Virol, 2009, 83:1312-1319.
  • 4Fletcher NF, Wilson GK, Murray J, et al. Hepatitis C virus infects the endothelial cells of the blood-brain barrier. Gastroenterology, 2012, 142:634-643 e6.
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  • 6Morgello S, Estanislao L, Ryan E, et al. Effects of hepatic function and hepatitis C virus on the nervous system assessment of advanced-stage HIV-infected individuals. AIDS, 2005, 19 Suppl 3 :S116-22.
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  • 8Fletcher NF, Yang JP, Farquhar M J, et al. Hepatitis C virus infection of neuroepithelioma cell lines. Gastroenterology, 2010, 139 : 1365-1374.
  • 9Cherner M, Letendre S, Heaton RK, et al. Hepatitis C augments cognitive deficits associated with HIV infection and methamphetamine. Neurology, 2005, 64 : 1343-1347.
  • 10McAndrews MP, Farcnik K, Carlen P, et al. Prevalence and significance of neurocognitive dysfunction in hepatitis C in the absence of correlated risk factors. Hepatology, 2005, 41:801- 808.

二级参考文献33

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  • 7Hsu M,Zhang J,Flint M,et al.Hepatitis C virus glycopmteins mediate pH-dependent cell entry of pseudotyped retroviral particles.Proc Natl Acad Sci U S A,2003,100:7271-7276.
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  • 9Lavillette D,Pecheur El,Donot P,et al.Characterization of fusion determinants points to the Involvement of three discrete regions of both E1 and E2 glycoproteins in the membrane fusion process of hepatitis C virus.J Virol,2007,81:8752-8765.
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共引文献7

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中华实验和临床病毒学杂志
2013年 第2期

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