摘要
目的 :应用凝血酶与碳酸氢钠治疗重症肺炎并发消化道出血的临床对比。方法 :将 2 0 0 0U～ 40 0 0U凝血酶溶于 5 0～ 10 0mL 0 .9%盐水或冰牛奶中 ,短时间内分次口服或鼻饲注入 ,每 6h重复应用 ,并与碳酸氢钠洗胃止血时间进行比较。根据抽吸胃液中有无血液或咖啡样物质判断是否止血。结果 :凝血酶止血所需时间短 ,显效率 77.0 8% ,总有效率 93 .75 % ,碳酸氢钠洗胃止血显效率 47.6 2 % ,总有效率 78.5 7% ,经统计学处理 ,P <0 .0 5 ,二者差异显著。结论 :凝血酶止血显效率明显优于碳酸氢钠组 ,同时避免了因碳酸氢钠产气所致胃扩张及胸廓顺应性降低等副作用。
To study the effect of thrombin and bicarbonate sodium on sever pneumonia complicated with gastrointestinal hemorrhage, 2 000-4000 U thrombin was in normal saline 50-100 ml saline and iced milk and was repeatedly administered orally or by nasal feeding with an interval of 6 hours. The results were compared with those of gastric lavage of bicarbonate sodium alone. The hemostatic effect was judged by observing the blood or coffee-like substances in gastric fluid collected. Our results showed that thrombin is quick in achieving hemostatic effect and the effective rate was 77.8%, with a total effective rate of 93.75%. The effective rate of gastric lavage by bicarbonate sodium was 47.63%, with a total effective rate 78.57%. Statistical analysis showed that the difference was significant ( P<0.05 ). Our study suggested that thrombin is better than bicarbonate sodium in hemostatic effect and it can avoid the lowered thoracic compliance caused by use of bicarbonate sodium and other effects.
出处
《药物流行病学杂志》
CAS
2000年第3期122-123,共2页
Chinese Journal of Pharmacoepidemiology
关键词
凝血酶
肺炎
消化道出血
胸廓顺应性
治疗
Thrombin
Severe pneumonia
Gastrointestinal tract
Thoracic compliance
