摘要
目的总结肝血管瘤瘤体内注射盐酸平阳霉素的临床疗效。方法对60例肝血管瘤患者行CT或彩色多普勒超声(彩超)引导下经皮穿刺注射盐酸平阳霉素(含平阳霉素8～16 mg、利多卡因3 ml)。术后采用彩超或CT随访6个月～1年,观察患者治疗前后临床症状、肝血管瘤瘤体大小的变化及不良反应。结果 60例患者中治疗1次38例,治疗2次13例,治疗3次9例,结果显示完全缓解5例,部分缓解54例,无变化1例。彩超或CT示瘤体内血流消失。术后8例出现低热,5例出现头晕伴胸闷,3例出现上腹痛伴呼吸困难,7例出现恶心、呕吐,对症处理后症状消失。未有患者出现骨髓抑制及肝功能损伤。结论肝血管瘤瘤体内注射盐酸平阳霉素安全、无严重并发症,是用于临床治疗肝血管瘤的有效方法,值得在临床上进一步观察推广及探讨。
Objective To evaluate the therapeutic efficacy of intratumoral injection of pingyangmycin for the treatment of hepatic hemangiomas. Methods Under CT or color ultrasound guidance, intratumoral injection of pingyangmycin （8- 16 mg pingyangmycin with 3 ml lidocaine） was carried out in 60 patients with hepatic hemangiomas. All the patients were followed up for 6 - 12 months with color ultrasound or CT scanning to determine the tumor＇s size. After the treatment the patient＇s clinical condition was evaluated and the occurrence of untoward reactions was recorded. The imaging findings were compared with those observed before the treatment. Results Single, twice and three times of intratumoral injection treatment were employed in 38, 13 and 9 patients respectively. Complete remission （CR） was achieved in 5 cases, partial remission（PR） in 54 cases and no change （NC） in one case. Color Doppler ultrasonography or CT examination performed after the treatment showed that the intratumoral blood flow vanished. The adverse effects included mild fever （n = 8）, dizziness with chest distress （n = 5）, upper abdominal pain with dyspnea （n = 3 ）, and nausea with vomiting （n = 7）, all of which disappeared after symptomatic treatment. Neither bone marrow depression nor hepatic dysfunction occurred. Conclusion For the treatment of hepatic hemangiomas, intratumoral injection of pingyangmyein is quite safe with no severe complications. This therapy has been proved to be an effective method, and should be recommended in clinical practice.
出处
《介入放射学杂志》
CSCD
北大核心
2013年第4期334-336,共3页
Journal of Interventional Radiology
关键词
肝血管瘤
平阳霉素
hepatic hemangioma
pingyangmycin
作者简介
通信作者：顾玉明E-mail：guyuming_2006@163．com.
