摘要
目的观察新辅助放化疗、热疗联合腹腔镜手术治疗进展期直肠癌的临床效果。方法选择2010年1月-2012年6月住院治疗的86例进展期直肠癌患者为研究对象,应用随机数字表法将本研究入选患者分为对照组和观察组,每组43人,对照组患者进行新辅助放化疗联合腹腔镜手术治疗,而观察组患者则在术前新辅助放化疗和热疗后再行腹腔镜手术治疗,比较对照组和观察组患者临床疗效和放化疗反应发生情况,比较对照组和观察组患者局部复发的情况。结果观察组患者的治疗总有效率(70.09%)明显高于对照组患者(51.16%),差异有统计学意义(P<0.05),而观察组的放化疗反应并未较对照组患者明显增加(P>0.05)。结论新辅助放化疗、热疗联合腹腔镜手术治疗进展期直肠癌临床疗效确切,不良反应少,明显改善患者的预后,远期疗效有待进一步观察。
Objective To observe the neoadjuvant chemotherapy,the clinical effects of hyperthermia combined with laparoscopic surgery for advanced rectal cancer.Methods 86 cases of advanced cancer patients in our hospital from January 2010 to June 2012 were set as the research object,the random number table,the study enrolled patients were divided into（cases=43） and observation group（cases=43）,control group patients neoadjuvant chemoradiotherapy and laparoscopy surgery,The patients in the neoadjuvant chemotherapy and radiotherapy and hyperthermia after laparoscopic surgery,and compare the control group and observation group in patients with clinical efficacy and adverse drug reactions occur,and to compare the control group and observation group of local recurrence in patients with a 2-year follow-up of two groups of patients.Results Total efficiency of treatment in observation group（70.09%） was significantly higher than that of control group patients（51.16%）,the difference was significant（P0.05）,while drug side effects were not significantly different between the two groups（P0.05）.Conclusion Neoadjuvant chemotherapy and radiotherapy,hyperthermia combined with laparoscopic surgery was good for advanced rectal cancer with ideal clinical efficacy and little adverse reactions,which can significantly improve the prognosis of patients,but the long-term outcome need to be further investigated.
出处
《中华全科医学》
2013年第3期348-349,468,共3页
Chinese Journal of General Practice
基金
广东省卫生厅课题(2011035321)
关键词
新辅助放化疗
热疗
腹腔镜手术
进展期直肠癌
局部复发
Neoadjuvant chemotherapy and radiotherapy
Hyperthermia
Laparoscopic surgery
Advanced rectal cancer
Local recurrence
