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促红细胞生成素治疗肿瘤相关性贫血的临床观察 被引量:6

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摘要 目的:探讨促红细胞生成素(EPO)治疗肿瘤相关性贫血的疗效和安全性。方法:将70例恶性肿瘤相关性贫血患者随机分为3组,其中蔗糖铁组24例,采用蔗糖铁200 mg加入生理盐水250 ml,静脉滴注,每周3次,连续6周;EPO组23例,给予EPO 100~150 IU/kg,皮下注射,每周3次,连续6周;蔗糖铁+EPO组23例,上述2种药物联合应用,连续6周。各组在对症处理,营养支持上相同,且均不放化疗联用。6周后比较各组疗效。结果:蔗糖铁组有效率54.2%,EPO组有效率82.6%,蔗糖铁+EPO组有效率95.7%。EPO组患者血红蛋白、红细胞、红细胞比容的上升幅度均优于蔗糖铁组(P<0.05~P<0.01)。结论:EPO治疗肿瘤相关性贫血疗效肯定,不良反应小,能够明显改善患者生活质量,有利于放化疗的施治。
出处 《蚌埠医学院学报》 CAS 2013年第2期186-188,共3页 Journal of Bengbu Medical College
作者简介 王曙光(1958-),男,副主任医师
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  • 1Ludwig H, Van Belle S, Barrett-Lee P,et al. The European Cancer Anaemia Survey (ECAS): A large, multinational, prospective survey defining the prevalence, incidence, and treatment of anaemia in cancer patients [ J ]. Eur J Cancer, 2004,40 ( 15 ) : 2293 - 2296.
  • 2马军,王杰军,张力,石远凯,朱军,王健民,陆舜,孙燕,廖美琳,管忠震,秦叔逵,王耀,张锦翔.EPO治疗肿瘤相关性贫血中国专家共识(2010-2011版)[J].临床肿瘤学杂志,2010,15(10):925-936. 被引量:70
  • 3Gordon MS. Managing anemia in the cancer patient:old problems, future solutions[J]. Oncologist,2002,7 (4) :331 - 341.
  • 4Itri LM. Managing cancer-related anaemia with epaetin alfa [ J ]. Nephml Dial Transplant,2002,17( Suppl 1 ) :73 - 77.
  • 5Yu JL, Coomber BL, Kerbel RS. A paradigm for therapy-induced ml tal changes in solid tumors leading to drug resistance [ J ]. Differentiation,2002,70 (9/10) :599 - 600.
  • 6Vaupel P, Thews O, Hoeckel M. Treatment resistance of solid minors:Role of hypoxia and anemia [ J]. Med Oncol, 2001,18(4) :243 -246.
  • 7Vaupel P,Mayer A. Hypoxia and anemia:Effects on tumor biology and treatment resistance [ J ]. Transfus Clin Biol, 2005, 12 ( 1 ) : 5-6.
  • 8Michiels C,Minet E,Mottet D,et a/. Regulation of gene expr ,sion by oxygen:NF-KB and HIF-1 ,two extremes[ J ]. Free Radie Biol Med, 2002,33(9) :1231 - 1242.
  • 9Zhou J, Callapina M, Goodall G J, et al. Functional integrity of nuclear factor kappaB, phosphate-dylinositol 3'-kinase, and mitogen activated protein kinase signaling allows tumor necrosis factor alpha-evoked Bcl-2 expression to provoke internal ribosome entry site-dependent translation of hypoxia-inducible factor lot [J]. Cancer Res,2004,64(24):9041 -9048.
  • 10刘小芳,王凌云,杜涛,李俐佳,胡小彦,钟筑宁.血清EPO及sTfR水平与恶性肿瘤性贫血的相关性研究[J].中国肿瘤临床与康复,2010,17(2):107-110. 被引量:9

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  • 1杨前生.促红细胞生成素治疗肿瘤相关性贫血临床分析[J].医学信息(医学与计算机应用),2014,0(18):231-231. 被引量:3
  • 2张渝华,张勤.促红细胞生成素的器官保护作用研究进展[J].重庆医学,2005,34(8):1244-1246. 被引量:5
  • 3Aerts JG, Swieboda - Sadlej A, Karanikiotis C, et al. Use of darbepoe- tin alfa in European clinical practice for the management of chemothera- py -induced anaemia in four tumour types:final data from the CHOICE study[J]. Curt Med Res Opin, 2012,28(7) :1089 -1099.
  • 4Xu CA, Chang ZY, Wang X J, et al. Doublets versus single - agent therapy as first - line therapy for elderly patients with advanced non - small cell lung cancer? A systematic review of randomised controlled tri- Ms[J]. Int J Clin Pract, 2013,67(11) :1118 -1127.
  • 5G61ffy G. The treatment of chemotherapy - induced anemia in lung cancer patients[J]. Magy Onkol, 2013,57( 1 ):39 -49.
  • 6Takahashi T, Yamamoto N, Tamura T, et al. Pharmacokinetic and pharmacodynamic profiles of subcutaneous administration of continuous erythropoietin receptor activator in lung cancer patients with anemia in- duced by chemotherapy [ J]. Oncol Lett, 2011,2 (6) :1033 -1040.
  • 7R6zs6s A, Berta J, Rojk6 L, et al. Erythropoietin receptor expression is a potential prognostic factor in human lung adenocarcinoma [ J ]. PLoS One, 2013,8(10) :e77459.
  • 8Ludwig H, Van Belle S, Barrett Lee P, et al. The Europe an Cancer Anaemia Survey (ECAS) : alarge, multination- al, prospective surving the prevalence, incidence, and treatment of anaemia in cancer patients[J].Eur J Cancer, 2004,40 (15) : 2293-2306.
  • 9Birgegard G, Aapro MS, Bokemeyer C, et al. Cancer-relat- ed anemia : pathogenesis, prevalence and treatment[J]. On- cology, 2005,68 Suppll : S3-11.
  • 10Rizzo JD, Lichtin AE, Woolf SH, et al. Use of epoetinin patients with cancer:evidence-based clactice guidelines of the American Society of Clinical Oncology and American Society of Hematology[J]. J Clin Oncol, 2006,20 (19) : 4083-4107.

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