摘要
目的评价无创通气联合噻托溴铵在COPD伴Ⅱ型呼吸衰竭的临床疗效。方法将126例老年COPD合并Ⅱ型呼吸衰竭患者随机分入对照组与观察组,对照组患者接受常规治疗,观察组患者在常规治疗基础上给予无创通气联合噻托溴铵吸入,疗程4周。比较两组治疗后4周血气分析指标及肺功能的改变。结果治疗后4周观察组血气分析指标PaO2、PaCO2及pH值均显著优于对照组,差别具有统计学意义(P<0.05);与对照组相比,治疗后观察组肺功能指标FEV1、FVC和FEV1/FVC显著提高(P<0.05)。结论无创通气联合噻托溴铵治疗老年COPD合并Ⅱ型呼吸衰竭可显著改善血气分析指标及肺功能,提高生活质量。
Objective To evaluate the clinical effect of non-invasive mechanical ventilation combined with tiotropium bromide in the treatment of elderly COPD patients with type B respiratory failure. Methods 126 elderly COPD patients with type Ⅱ respiratory fail- ure were randomly divided into the control group and the experience group. The control group received the routine treatment and the expe- rience group was given non-invasive mechanical ventilation combined with tiotropium bromide treatment on the basis of the routine treat- ment. The course of treatment was 4 weeks. The indexes of blood gas analysis and lung function 4 weeks after the treatment were compared between the two groups. Results The levels of PaO2 , PaCO2 and pH value 4 weeks after the treatment in the experience group were su- perior to the control group with significant difference （ P 〈 0. 05 ）. The improvement of FEVz , FVC and FEVl/FVC after the treatment was more pronounced in the experience group than in the control group （ P 〈 0.05 ）. Conclusion Non-invasive mechanical ventilation combined with tiotropium bromide can greatly improve the indexes of blood gas analysis, lung function and life quality in the treatment of elderly COPD patients with type Ⅱ respiratory failure.
出处
《临床肺科杂志》
2013年第4期677-678,共2页
Journal of Clinical Pulmonary Medicine
关键词
慢性阻塞性肺疾病
无创通气
噻托溴铵
chronic obstructive pulmonary disease
non-invasive mechanical ventilation
tiotropium bromide
