摘要
目的 研究苦参碱和氧化苦参碱对二乙基亚硝胺诱发大鼠肝癌作用的影响。方法 采用二乙基亚硝胺法诱发大鼠肝癌 ,观察腹腔注射苦参碱 2 5mg·kg-1和氧化苦参碱10 5mg·kg-130d后 ,大鼠肝表面癌结节数、肝 /体重比和血清中丙氨酸氨基转移酶 (ALT)、γ 谷氨酰转肽酶 (γ GT)、碱性磷酸酶 (ALP)的变化。结果 氧化苦参碱组大鼠肝表面癌结节数、肝 /体重比和血清ALT、γ GT明显低于模型组 (P<0 0 5 ) ;苦参碱组大鼠肝表面癌结节数和血清γ GT明显低于模型组 (P <0 0 5 )。结论 苦参碱和氧化苦参碱 ,尤其是氧化苦参碱 ,不仅能保护肝细胞免受损伤 。
AIM To study the effects of matrine (MT) and oxymatrime (OMT) on rat hepatoma induced by diethylnitrosamine (DEN). METHODS Hepatoma rats induced by DEN for 90 days , were administered with MT 25 mg·kg -1 or OMT 105 mg·kg -1 for 30 days intraperitioneally.The changes of hepatoma nuts and body weight, liver weight, ratio of liver/body weight were recorded and the alanine aminotransterase (ALT), γ glutamyl transferase (γ GT) and alkaline phosphatase (ALP) in serum and the pathological changes of the livers were observed. RESULTS The hepatoma nuts, ratio of liver/body weight serum ALT andγ GT were lower in OMT group compared with model group, while significant changes of hepatoma nodules and γ GT were found in MT group. CONCLUSION MT and OMT, especially OMT, can protect liver cells from damage and inhibit the proliviration of hepatoma cells.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2000年第4期416-417,共2页
Chinese Pharmacological Bulletin
基金
"九五"军队医药卫生科研基金资助课题!
No 98D0 42
