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IP方案二线治疗广泛期小细胞肺癌的临床研究

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摘要 目的观察IP方案二线治疗广泛期小细胞肺癌的疗效及安全性。方法对一线治疗失败的54例广泛期小细胞肺癌患者采用IP方案二线治疗:伊立替康80mg/m^2,第1、8、15天静脉滴注,顺铂35mg/m^2,第1-4天静脉滴注,28d为1个周期。结果完全缓解4例,部分缓解9例,稳定14例,进展27例。临床有效率24.1%(13/54),临床获益率50。0%(27,54)。常见不良反应为白细胞减少、血小板减少、贫血、恶心呕吐、腹泻、肝功能损伤。Ⅲ~Ⅳ级上述不良反应发生率分别为53.7%(29/54)、16.7%(9/54)、9.3%(5/54)、14.8%(8/54)、35.2%(19/54)、3.7%(2/54)。结论IP方案二线治疗广泛期小细胞肺癌有一定疗效,临床获益率高,不良反应可耐受。
出处 《中国医师进修杂志》 2013年第6期53-54,共2页 Chinese Journal of Postgraduates of Medicine
作者简介 通信作者:张春盈,Email.zcy196301028@126.com
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