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IgA肾病的病因进展及治疗现状 被引量：6

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摘要 IgA肾病（IgA nephropathy，IgAN）的发病机制取得了一些进展，但仍不十分明确。目前认为，遗传、环境和免疫因素共同决定了IgAN的发病。遗传因素，尤其是半乳糖缺乏的IgAl（galactose-deficient IgAl，Gd—IgAl）生成过多是IgAN发病机制的始动因素．而IgA免疫复合物形成是IgAN发生的中心环节[1]。
作者 邹敏书 余健 周建华
机构地区 广州军区武汉总医院儿科 华中科技大学同济医学院同济医院儿科
出处 《临床肾脏病杂志》 2013年第2期91-93,共3页 Journal Of Clinical Nephrology
基金 国家自然科学基金面上资助项目（NQ81070557）
关键词 IGA肾病 IgA免疫复合物 治疗 病因 IGAN 发病机制 遗传因素 共同决定
分类号 R692.31 [医药卫生—泌尿科学]
作者简介 通信作者：周建华，E-mail：jhzhou@tjh．tjmu．edu．cn
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参考文献24

  • 1Boyd JK,Cheung CK,Molyneux K,et al. An update on the path- ogenesis and treatment of IgA nephropathy. Kidney Int, 2012, 81:833-843.
  • 2Lai KN. Pathogenesis of IgA nephropathy. Nat Rev Nephrol, 2012,8:275-283.
  • 3Floege J. The pathogenesis of IgA nephropathy., what is new and how does it change therapeutic approaches? Am J Kidney ]Dis, 2011,58 : 992-1004.
  • 4Schena FP, Cerullo G, Rossini M, et al. Increased risk of end- stage renal disease in familial IgA nephropathy. J Am Soc Neph- rol, 2002,13:453-460.
  • 5Feehally J, Farrall M, Boland A, et al. HLA has strongest associ- ation with IgA nephropathy in genome-wide aaaalysis. J Am Soc Nephrol,2010,21 : 1791-1797.
  • 6Gharavi AG, Kiryluk K, Choi M, et al. Genomewide association study identifies susceptibility loci for IgA nephropathy. Nat Gen- et, 2011,43:321-327.
  • 7Hastings MC, Moldoveanu Z, Julian BA, et al. Galactose-deficient IgA1 in African Americans with IgA nephropathy: serum levels and heritability. Clin J Am Soc Nephrol, 2010,5 : 2069-2074.
  • 8Kiryluk K, Moldoveanu Z, Sanders JT, et al. Aberrant glycosyla- tion of IgA1 is inherited in both pediatric IgA nephropathy and Henoeh-Sch? nlein purpura nephritis. Kidney Int, 2011,8(1: 79- 87. G.
  • 9haravi ACT, Moldoveanu Z,Wyatt R J, et al. Aberrant IgA1 gly- cosylation is inherited in familial and sporadic IgA nephropathy. J Am Soc Nephrol,2008,19: 1008-1014.
  • 10Smerud HK, tkirriny P, Lindstr? m K, et al. New treatment for IgA nephropathy: enteric budesonide targeted to the ileocecal re- gion ameliorates proteinuria. Nephrol Dial Transplant, 2011,26: 3237-3242.

同被引文献69

  • 1黎磊石,刘志红.肾小球疾病免疫抑制剂治疗的新方向——多靶点免疫抑制治疗[J].肾脏病与透析肾移植杂志,2007,16(1):3-4. 被引量：35
  • 2Moldoveanu Z, Wyatt R J, Lee JY, et al. Patients with IgA nephropa- thy have increased serum galactose-deficient IgA1 levels [J]. Kidney Int,2007,71(11): 1149-1154.
  • 3Zhao N, Hou P, Lv J, et al. The level of galactose-deficient IgA1 in the sera of patients with IgA nephropathy is associated with disease progression [J]. Kidney Int, 2012,82(7): 790-796.
  • 4Kiryluk K, Moldoveanu Z, Sanders JT, et al. Aberrant glycosylation of IgAl is inherited in pediatric lgA nephropathy and Henoch-Sch6 nlein purpura nephritis [J]. Kidney Int, 2011,80(1): 79-87.
  • 5Gharavi AG, Moldoveanu Z, Wyatt R J, et al. Aberrant IgAl glyco- sylation is inherited in familial and sporadic IgA nephropathy [J]. J Am Soc Nephrol,2008, 19(5): 1008-1014.
  • 6Iwase H, Ishii-Karakasa I, Fujii E, et al. Analysis of glycoform of O- glycan from human myeloma immnunoglobulin A1 by gas-phase hy- drazinolysis is following pyridylamination of oligosaccharides [J], Anal Biochem, 1992,206(1) : 202-205.
  • 7Nakata J, Suzuki Y, Suzuki H, et al. Experimental evidence of celldissemination playing a role in pathogenesis of IgA nephropathy in multiple lymphoid organs [J]. Nephrol Dial Transplant, 2013, 28 (2) : 320-326.
  • 8Suzuki H, Fan R, Zhang Z, et al. Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with re- stricted heterogeneity [J]. J Clin Invest, 2009, 119(6) : 1668-1677.
  • 9Tomana M, Novak J, Jullian BA, et al. Circulating immune complex- es in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies [J]. J Clin Invest, 1999, 104(1): 73- 81.
  • 10Crisp HC, Quinn JM. Quantitative immunoglobulins in adulthood [J]. Allergy Asthma Proc, 2009,30(6) : 649-654.

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临床肾脏病杂志
2013年 第2期

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