摘要
目的 探讨TNF-α基因在肺癌组织中的表达及其临床意义。方法 应用免疫组化SP法检测40例肺癌组织中肿瘤坏死因子(Tumor necrosis factor,TNF-α)的表达，并与癌旁正常肺组织对照。结果 TNF-α阳性表达主要分布于癌细胞胞浆中，阳性率为47..5%(19/40)，细胞核内无阳性表达；癌旁正常肺组织内无阳性表达(P＜0..05)。结论 TNF-α与肺癌的发生、发展有着密切关系。
Objective\ To detect TNFα in the tissue of primary b ronchogenic carcinoma(PBC) and discuss its significance.Methods\ TNF α was assessed by immunohistochemical method of SP in paraffin tissue secti ons of 40 PBC and paratumor normal lung tissue.Results\ The positive rate of TNFα in cytoplasm of carcinoma cells was 47.5%(19/40),and it was not found in all paratumor normal lung tissue(P＜0.05).Conclusion\ TNF α gene expressed in some patients with bronchogenic carcinoma.The growth of b ronchogenic carcinoma is related to TNFα gene.
出处
《西安医科大学学报》
CAS
CSCD
2000年第5期425-427,共3页
Journal of Xi'an Medical University(Chinese)
关键词
肺肿瘤
肿瘤坏死因子
免疫组织化学
lung neoplasm
tumor necrosis factor
immunohist ochemistry
