摘要
目的:探讨住院的慢性肾脏病(Chronic kidney disease,CKD)患者中代谢综合征(Metabolic syndrome,MS)的患病率及慢性肾脏病合并代谢综合征的相关危险因素,以及合并MS患者的中医证型,为中医药防治慢性肾脏病提供理论依据。方法:收集2011年7月～2012年7月我院肾内科住院患者308例的临床资料进行回顾性分析。按有、无代谢综合征进行分组,探讨慢性肾脏病合并代谢综合征的相关危险因素,以及合并MS患者的辨证分型。统计学方法包括t’检验、卡方检验和logistic多因素回归分析。结果:住院慢性肾脏病患者中代谢综合征的患病率为31.81%;代谢综合征各组成因子中,血糖和肥胖是代谢综合征中与慢性肾脏病相关性最高的危险因素,优势比(OR)分别为2.42、2.29;肾小球滤过率和24小时蛋白尿也是慢性肾脏病相关危险因素,优势比分别为2.53和3.13;合并MS患者中以痰瘀互结型比例最高,BMI最高,肾脏损伤最重。结论:住院慢性肾脏病患者中代谢综合征的患病率明显高于普通人群,而高血糖、肥胖、蛋白尿、肾小球滤过率的下降是住院慢性肾脏病患者合并代谢综合征最重要的危险因素,痰瘀互结是合并MS的辨证特点,是CKD发展的病理基础。
Objective： To investigate the prevalence of metabolic syndrome in the in-patient department of Nephrology, analysis of the associated risk factors and types of TCM , for the prevention and control of chronic kidney disease （CKD） of traditional Chinese medicine to provide a theoretical basis. Methods： A cross-sectional retrospective study was performed with 308 patients who were admitted to the in-patient department o f Nephrology in our hospital during July lst ,2011 to July 1st 2012. The patients were divided into two groups according to whether the CKD patients accomanyed with metabolic syndrome or not. TCM types and the association between the components of metabolic syndrome and chronic kidney disease were investigated. Statistical methods including t, test, chi-square test and logistic regression analysis. Results： The prevalence of metabolic syndrome in the hospitalized chronic kidney disease patients was 31.81%. Among the components of metabolic syndrome, high blood glucose and obesity were the most important risk factors for chronic kidney disease, the odds ratio were 2.42 and 2. 29 respectively. Glomerular filtration rate and 24-hours urinary protein are risk factors for chronic kidney disease, the odds ratio were 2.53 and 3.31 respectively. MS patients combined with phlegm and blood stasis mutual junction were highest percentage, whose BMI were highest, kidney damages were the heaviest. Conclusion： The prevalence of metabolic syndrome in patient with chronic kidney disease was significantly higher than the general population. High blood glucose, obesity , 24-hours urinary protein and Glomerular filtration rate were most important risk factors for chronic kidney disease.＂ Phlegm accumulating with blood stasis is MS dialectical feature and the development of CKD pathological basis.
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2013年第2期163-165,共3页
JOURNAL OF BASIC CHINESE MEDICINE
作者简介
左海宁（1974-），男，河北乐亭人，主治医师，医学本科，从事内科的临床与研究。
通讯作者：王洪霞（1971-），女，北京人，医学硕士，从事临床肾病研究，E-mail：whxxy@sohu．com。
