摘要
目的观察丹红注射液治疗慢性阻塞性肺疾病急性加重期患者肿瘤坏死因子-α(TNF-α)和白细胞介素-8(IL-8)的影响。方法将100例慢性阻塞性肺疾病急性加重期患者随机分为治疗组(52例)和对照组(48例),两组均给予常规对症治疗(抗感染、平喘、化痰及吸氧等),治疗组在常规治疗基础上应用丹红注射液40 mL+0.9%氯化钠注射液250 mL,日1次静滴,疗程14天。观察两组患者症状、体征、血气分析及肺功能指标的变化,同时检测两组患者血清TNF-α和IL-8水平的变化。结果治疗组临床疗效的总有效率优于对照组(P<0.05);治疗组血清中TNF-α和IL-8浓度较对照组下降,差异有统计学意义(P<0.05或P<0.01)。结论丹红注射液可降低COPD急性加重期血清中TNF-α和IL-8浓度,抑制炎症细胞生成,对COPD气道炎症具有明显的抑制作用。
Objective To observe the influence of Danhong injection on treating tumor necrosis factor-alpha （TNF-alpha） and interleukin-8 （IL-8） of chronic obstructive pulmonary disease in acute exacerbation. Methods 100 patients of chronic obstructive pulmonary disease in acute exacerbation were randomly divided into the treatment group （52 cases） and the control group （48 cases）, conventional symptomatic treatments （ anti-inflection, asthma preventing, phlegm reduction, oxygen inhalation and the like） were applied to both the groups, 40 mL Danhong injection and 250 mL 0. 9% sodium chloride injection were also used for the treatment group aside from the conventional treatment, while at the same time with an intravenous drip per day for the period of 14 days. Signs and symptoms, vigor analysis, and index changes of lung function of the patients of the two groups were observed, and the changes of blood serum TNF-alpha and IL-8 level of the patients in the two groups were detected. Results The overall clinical effectiveness of the treatment group was better than that of the control group （P 〈 0.05 ）, the TNF-alpha and IL-8 concentrations in the blood serum of the treatment group were lower than those of the control group, and the difference was statistically significant （ P 〈 0. 05 or P 〈 0. 01 ）. Conclusion Danhong injection can reduce the TNF-alpha and IL-8 concentrations in blood serums of the COPD in acute exacerbation, can inhibit the generation of inflammatory cells and play a prominent role in inhibiting the COPD airway inflammation.
出处
《辽宁医学院学报》
CAS
2013年第1期23-25,共3页
Journal of Liaoning Medical University (LNMU) Bimonthly
作者简介
陈卓（1972），女，辽宁锦州人，主治医师，学士学位，主要研究方向为临床呼吸科疾病诊断与治疗。
通讯作者：刘忠（1968），女，山西清徐人，副主任医师，硕士学位，主要研究方向为呼吸科疾病诊断与治疗。
