摘要
目的系统评价超重、肥胖与2型糖尿病(T2DM)发病风险的相关性。方法计算机检索PubMed、EMbase、The Cochrane Library(2012年第3期)、CNKI、VIP、CBM和WanFang Data,查找关于超重、肥胖与T2DM发病风险相关性的队列研究,检索时限均从建库至2012年5月。由2位研究者严格按照纳入与排除标准筛选文献、提取资料并评价质量后,采用RevMan 5.1和Stata 11.0软件进行Meta分析。结果最终纳入8个研究,共101 864例研究对象。Meta分析结果显示:与正常体重人群相比,超重和肥胖人群的T2DM发病风险均明显增高[超重:RR=2.59,95%CI(2.11,3.19),P<0.000 01;肥胖:RR=6.28,95%CI(4.99,7.91),P<0.000 01]。西方肥胖人群的T2DM发病风险[RR=6.91,95%CI(5.59,8.56)]高于东方人群[RR=4.19,95%CI(2.93,5.99)]。将超重和肥胖对T2DM发病影响的研究按GRADE系统推荐分级,质量分别为低级和中等。结论超重、肥胖均能增加T2DM的发病风险,且女性肥胖人群比男性发病风险高,西方肥胖人群比东方肥胖人群发病风险高。
Objective To explore the correlation between overweight, obesity and incidence of type 2 diabetes mellitus （T2DM）. Methods Databases including PubMed, EMbase, The Cochrane Library （Issue 3, 2012）, CNKI, VIP, CBM and WanFang Data were searched from inception to May, 2012 to collect the cohort studies on the correlation be- tween overweight, obesity and incidence of T2DM. The studies were screened according to the inclusion and exclusion criteria by two researchers independently, the quality was evaluated, the data were extracted, and then meta-analysis was performed using RevMan 5.1 and Stata 11.0 software. Results A total of 8 studies involving 101 864 participants were included. The results of meta-analysis showed that, compared with the normal weight population, the onset risk of T2DM was obviously higher in the overweight （RR--2.59, 95%CI 2.11 to 3.19, P〈0.000 01）, and obese （RR=6.28, 95%CI 4.99 to 7.91, P〈0.000 01） populations. In the subgroup analysis, the onset risk of T2DM was higher in the western obese population （RR=6.91, 95%CI 5.59 to 8.56） than the eastern obese population （RR--4.19, 95%CI 2.93 to 5.99）. Based on the Grading of Recommendations Assessment, Development and Evaluation （GRADE）, the quality of the included studies on T2DM de- veloped by overweight and obesity was low and medium respectively. Conclusion Overweight and obesity can increase the onset risk of T2DM which is higher in the female and western obese populations than the male and eastern obese populations respectively.
出处
《中国循证医学杂志》
CSCD
2013年第2期190-195,共6页
Chinese Journal of Evidence-based Medicine
关键词
超重
肥胖
2型糖尿病
系统评价
META分析
队列研究
Overweight
Obesity
Type 2 Ddiabetes mellitus
Systematic review
Meta-analysis
Cohort study
作者简介
刘俊，女（1987年～），硕士研究生，研究方向为慢性病流行病学。Email：yuanye-4@126．com
通讯作者，Emaihqjunzhang@163．com
