摘要
目的观察冠心病患者经皮冠状动脉介入术(PCI)治疗前后miR-92a的表达变化及意义。方法 36例冠心病患者(观察组)按病情程度分为稳定型心绞痛(9例)、不稳定型心绞痛(9例)、ST段抬高型心肌梗死(9例)、非ST段抬高型心肌梗死(9例),均行PCI,另选3例健康体检者作对照(对照组),采用实时荧光定量PCR技术检测术前及术后1、5 d miR-92a。结果与对照组比较,观察组miR-92a表达随病情程度加重而升高(P均<0.05);与同组术前比较,术后miR-92a表达均降低(P均<0.05)。结论冠心病患者miR-92a表达随病情程度加重而升高,PCI可降低冠心病患者miR-92a表达。
Objective To investgate the expression and significance of miR-92a before and after percutaneous coronary intervention（PCI） treatment in patients with coronary heart disease. Methods Thirty-six patients with coronary heart disease （observed group） was divided into stable angina 9 cases, unstable angina 9 cases, ST-segment elevation myocardial infarction 9 cases, non-ST segment elevation myocardial infarction9 cases acrroding to the severity. All The patients were treated with PCI. Three healthy cases as control group was slected. The expression of miR-92a of these samples at different time （preoperative, postoperative 1 day, postoperative 5 days ） was detected by the application of real-time fluorescence quantitative PCR （RT-qPCR）. Results Compared with the control group, miR-92a expression level significantly in- creased with the severity in observed group （ all P 〈 0.05 ） ; miR-92a expression level in observed group after PCI was sig- nificantly lower than that before PCI （ all P 〈 0.05 ） . Conclusion miR-92a expression level in patients with coronary heart disease will increase with the severity, the treatment of PCI can decrease the expression of miR-92a in patients with coronary heart disease.
出处
《山东医药》
CAS
2013年第3期40-42,共3页
Shandong Medical Journal
基金
广东省科技计划资助项目(2010B031500030)
关键词
冠心病
经皮冠状动脉介入术
coronary heart disease
percutaneous coronary intervention
