摘要
非动脉炎性前部缺血性视神经病变（NAION）是引起中老年人视功能严重损害的常见视神经疾病，目前其发病机制尚不完全清楚，因此治疗效果并不理想，NAION的实验研究成为该病预防和治疗的方向，而建立较为理想的实验动物模型（包括啮齿类和灵长类动物）的研究已成为研究热点。近年来，NAION动物模型的建立方法不断进步，应用光动力学的方法成功建立的NAION模型使人们对该病的病理生理机制有了更加深入的了解，也为探索有效的治疗方法奠定了基础。就NAION动物模型制备过程中的实验动物选择、不同造模方法以及存在的问题进行分析综述，为进一步的实验研究提供参考。
Nonarteritie anterior ischemic optic neuropathy （NAION）is a common optic neuropathy seriously affecting the visual function in the middle-aged and elderly population. However, its pathogenesis is not completely clear,and therefore its treating efficacy is dissatisfactory. The current study on NAION is focused on the establishment of suitable animal model and the pathogenesis. In recent years, the relatively ideal animal models （ including rodent and primate） have been established by photodynamic methods, which make people have more in-depth understanding on the pathophysiologic mechanism of NAION and lay the basis for the research of therapies. The selection of experimental animals,various induction methods and existing problems in the creation of NAION animal model were reviewed and analyzed in this artical.
出处
《中华实验眼科杂志》
CAS
CSCD
北大核心
2013年第1期91-95,共5页
Chinese Journal Of Experimental Ophthalmology
基金
国家人力资源和社会保障部2012年度留学人员科技活动择优资助项目（人社厅函[2012]258号）
2012年河北省医学科学研究重点课题计划（20120067）
作者简介
通信作者：王建民，Email：wjmykys@yahoo．com.cn
