摘要
目的研究静吸复合麻醉中不同小剂量芬太尼对脑电边缘频率（ＳＥＦ）和双波谱指数（ＢＩＳ）的影响。方法随机将 ＡＳＡⅠ— Ⅱ 级病人 ３０例分为 Ⅰ、 Ⅱ、 Ⅲ组，于全麻诱导吸入安氟醚达０．８ＭＡＣ后，三组分别静注芬太尼３μｇ·ｋｇ－１、５μｇ·ｋｇ－１、７μｇ·ｋｇ－１，于给药后６ｍｉｎ记录每组病人的ＭＡＰ、ＨＲ，ＳＥＦ及ＢＩＳ。结果三组组内、组间ＭＡＰ、ＨＲ相比均无显著性差异（Ｐ＞０．０５）。与给药前相比， Ⅰ组给药后 ＳＥＦ显著性降低（ Ｐ＜ ０． ０５）， ＢＩＳ无显著性差异（ Ｐ＞ ０． ０５）， Ⅱ组给药后 ＳＥＦ、 ＢＩＳ均显著性降低（Ｐ＜０．０５），Ⅲ组ＳＥＦ、ＢＩＳ给药后均有极显著性降低（Ｐ＜０．０１）。给药前Ⅰ、Ⅱ及Ⅲ组相比ＳＥＦ、ＢＩＳ无显著性差异（Ｐ＞０．０５）。给药后三组间ＳＥＦ无统计学差异（Ｐ＞０．０５）；与Ⅰ组相比，Ⅲ组 ＢＩＳ给药后显著性降低（ Ｐ＜ ０．０１）。结论静吸复合麻醉中使用芬太尼 ３— ７μｇ· ｋｇ－１可降低ＳＥＦ、ＢＩＳ，增强全麻深度，明显减少全麻药的用量。
Objective To study the effect of different low-doses of fentanyl on spectral edge frequency(SEF) and bispectral index (BIS) during combined anesthesia. Methods After induction, the anesthesia was maintained with inhalation of enflurane at 0.8MAC. Thirthy adult patients, ASA grade Ⅰ- Ⅱ, were randomly allocated to receiving intraveneous fentanyl 3μg.kg-1 (group Ⅰ, n = 10), fentanyl 5μg .kg-1 (group Ⅱ, n = 10) or fentanyl 7μg. kg-1 (group Ⅲ, n = 10), respectively. MAP, HR, SEF and BIS were measured before and 6 min after the administration in each group. Results There were no significant differences in HR and MAP among three groups and between pre-and post--intraveneous fentanyl (P > 0.05). As compared with those before intraveneous fentanyl, after the administration, SEF decreased significantly (P<0.05) and BIS remained unsignificant change in group Ⅰ (P > 0.05 ); SEF and BIS decreased markedly in group Ⅱ (P < 0.05 ); SEF and BIS reduced obviously in group Ⅲ (P < 0.01 ). Before intravenous fentanyl there were unsignificant differences in SEF and BIS among three groups (P > 0.05); after the administration there were no remarkable differences in SEF among three groups (P > 0.05), but BIS was markedly lower in group Ⅲ than that in group Ⅰ (P < 0.01 ) .Conclusions Intravenous fentanyl of 3-7μg.kg-1 can depress SEF and BIS during combined anesthesia, indicating to deepen the depth of anesthesia and reduce the requirements of other anesthetics.
出处
《中华麻醉学杂志》
CSCD
北大核心
2000年第7期409-410,共2页
Chinese Journal of Anesthesiology
关键词
全身麻醉
芬太尼
边缘频率
双波谱指数
Anesthesia
general
Fentanyl
Spectral edge frequency
Bispectral index
