摘要
目的:探讨右美托咪啶在合并高血压行腹腔镜胆囊切除患者全麻期血流动力学的影响。方法:120例ASAⅠ-Ⅲ级合并高血压腹腔镜胆囊切除患者,随机分为右美托咪定组(右美组)和对照组。两组患者全麻诱导和维持相同,术前10mi n右美组患者10mi n内静脉泵注0.5ug/kg右旋美托咪啶,对照组患者以相同速率静脉泵注等量生理盐水。观察并记录围插管期和围拔管期SBP和HR、苏醒时间、拔管时间。结果:与给药前相比,对照组在气管插管即刻和拔除气管导管时以及气管拔管1mi nSBP和HR均显著性升高(P<0.05);右美组中,在气管插管即刻、拔除气管导管时、气管拔管1mi n和5mi nSBP和HR均无显著性差异(P>0.05)。与对照组比较,气管插管即刻、拔管时、拔管后1mi n,右美组SBP和HR明显下降(P<0.05)。结论:右美托咪啶能有效减轻合并高血压行腹腔镜胆囊切除患者全麻插管期的心血管应激反应。
Objective To investigate the effect of dexmedetomidine on hemotlynamics of hypertension patients underwent laproscopic cholecystectomy （LC） during General anesthesia. Methods 120 patients （ASA I-Ⅲ） with hypertension underwent LC were randomly divided into two groups. One is dexmedetomidine group （Dex group）, and the other is Control group （Con group）. The induction and maintenance of anesthesia of the two groups were identical. However, patients in Dex group were administered dexmedetomidine at a dose of 0.5ug/kg over 10 min and in Con group patients were given a placebo infusion of normal saline at identical rates at 10 min prior to the end of the operation（blindly）.Systolic blood pressure （SBP）, diastolic blood pressure （DBP）,heart rate （HR） , the recovery time, intubation time extubation time and adverse effects in periextubation were recorded. RPP were also calculated. Results SBP, DBP, HR,RPP in Dex group during intubation,extubation and 1rain post extubation were significantly lower than those in Con group （P〈0.05）. And even 5 min post extubation, RPP value in Dex group was still significantly lower than that in Con group （P〈0.05）. In addition,the above parameters were statistically elevated in Con group during intubation,extubation and 1 min post extubation compared to parameters before given saline （P〈0.05）. However, there is no statistical difference between Dex and saline group. Conclusion Dexmedetomidine could effectively attenuate the cardiovascular response to intubation and extubation in patients with hypertension underwent laproscopic cholecystectomy.
出处
《中国美容医学》
CAS
2012年第11X期189-190,共2页
Chinese Journal of Aesthetic Medicine
关键词
右旋美托咪啶
高血压
腹腔镜胆囊切除术
dexmedetomidine
hypertension
laproscopic cholecystectomy extubation
作者简介
杨晓玲（1981-），女，四川泸州人，本科，医师，研究方向：麻醉学。
