摘要
目的观察奥沙利铂联合卡培他滨在晚期胃癌治疗中的疗效及毒性反应。方法收集本科75例晚期胃癌患者为研究对象,所有患者均采用奥沙利铂+卡培他滨联合化疗方案,治疗结束后评价疗效并观察其毒性反应。结果 75例患者经过8个周期的治疗后,总有效46例,总有效率为61.33%。主要毒性反应有,骨髓抑制Ⅰ～Ⅱ度52例占69.33%,Ⅲ～Ⅳ度7例,占9.33%;恶心、呕吐37例,占49.33%。奥沙利铂所致神经毒性有51例,占68.00%;变态反应3例,占4.00%。卡培他滨所致手足综合征22例,占29.33%,其中Ⅲ度4例。结论奥沙利铂联合卡培他滨治疗晚期胃癌有较好疗效,毒性反应较轻,患者易于接受,值得在临床上进一步推广应用。
Objective To observe the curative effect and toxic reaction of oxaliplatin into joint capecitabine in the treatment of advanced gastric cancer.Methods The data of 75 patients with advanced gastric cancer in our department as the research object,all patients were used the oxaliplatin and capecitabine combination chemotherapy regimens,after the treatment the curative effect was evaluated and its toxic reaction was observeed.Results All 75 cases of patients after eight cycle after treatment,the total effective in 46 cases,the total effective rate was 61.33%.Main toxic reaction,bone marrow suppression Ⅰ to Ⅱ degrees in 52 cases（accounted for 69.33%）,Ⅲ to Ⅳ degrees in 7 cases（accounted for 9.33%）;Nausea,vomiting in 37 cases（accounted for 49.33%）.The nerve toxicity caused by Oxaliplatin in 51 cases（accounted for 68.00%）;Allergy in 3 cases（accounted for 4.00%）.The limbs syndrome caused by Capecitabine in 22 cases（accounted for 29.33%）,among them the Ⅲ degrees in 4 cases.Conclusion Oxaliplatin joint capecitabine treatment of advanced gastric cancer has a good curative effect,toxic reaction is lighter,easy to be accepted by the patients,it is worth in clinic further popularization and application.
出处
《中国当代医药》
2012年第36期71-72,共2页
China Modern Medicine
关键词
奥沙利铂
卡培他滨
晚期胃癌
毒性反应
Oxaliplatin into
Capecitabine
Advanced gastric cancer
Toxic reaction
作者简介
翁洁（1972-），女，副主任医师，硕士学历，研究方向：肿瘤化疗及放疗。
通讯作者：胡建兵（1967-），男，主任医师，研究方向：肿瘤放疗及综合治疗。
