摘要
目的探讨Delta样配体4(DLL4)和血管内皮生长因子(VEGF)蛋白在乳腺癌组织中的表达及意义。方法应用免疫组织化学法检测60例乳腺癌组织及20例癌旁正常乳腺组织中DLL4和VEGF蛋白的表达,分析两者与乳腺癌患者临床病理学特征的关系。结果 DLL4和VEGF蛋白在乳腺癌组织中的表达高于癌旁正常组织(P<0.05)。DLL4蛋白的表达与乳腺癌的组织学分级、临床分期、淋巴结转移、肿瘤直径有关(P<0.05),VEGF蛋白的表达与乳腺癌的组织学分级、临床分期、淋巴结转移均有关(P<0.05),两者在乳腺癌组织中的表达呈正相关(r=0.462,P<0.001)。结论 DLL4及VEGF蛋白表达与乳腺癌的浸润、转移密切相关,两者可能具有协同作用。
Objective To investigate the expressions and significance of Delta-like ligand 4（DLL4） and vascular endothelial growth factor（VEGF） proteins in breast cancer tissues.Methods Immunohistochemical method was used to detect the expression of DLL4 and VEGF in 60 cases of breast cancer tissues and 20 cases of adjacent normal breast tissues,and the relationship between DLL4 or VEGF expressions and clinicopathological features of breast cancer was analyzed.Results The expression of DLL4 and VEGF in breast cancer tissues were remarkably higher than those in normal breast tissues（P0.05）.The expressions of DLL4 in breast cancer were related with the histological grade,clinical stage,lymph node metastasis and diameter of tumor,the expressions of VEGF were in breast cancer were related with the histological grade,clinical stage and lymph node metastasis（P0.05）.The expressions of DLL4 were positively correlated to the expressions of VEGF（r=0.462,P0.001）.Conclusions The expressions of DLL4 and VEGF are related to invasion and metastasis of breast cancer,DLL4 and VEGF may have synergetic effects.
出处
《中国肿瘤临床与康复》
2012年第6期484-486,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
作者简介
作者简介：曹文庆，男，主治医师，主要从事乳腺甲状腺外科专业。
通信作者：张静，Email：bzgd2010@126．com.
