摘要
使临床医生了解嗜麦芽窄食单胞菌的耐药性并选择有效抗生素治疗其所致感染。方法 :采用K B纸片扩散法进行抗生素敏感试验 ,采用双纸片扩散法检测超广谱 β 内酰胺酶 (ESBL)。 结果 :嗜麦芽窄食单胞菌对大多数 β 内酰胺类抗生素耐药 ,对青霉素类抗生素 ,亚胺培南 ,一代、二代及三代头孢菌素中头孢曲松、头孢噻肟几乎 10 0 %耐药 ,在耐三代头孢类抗生素的嗜麦芽窄食单胞菌中有 77.4%的菌株产生超广谱 β 内酰胺酶 (ES BL) ,对氨基糖甙类抗生素中庆大霉素、阿米卡星也呈现出较高的耐药性 ;对环丙沙星耐药率最低 ,但耐药菌中度敏感数量均呈逐年递增趋势 ;复方新诺明耐药性 1996～ 1998年 3年中无明显变化 ,一直保持在 2 5 %左右。结论 :嗜麦芽窄食单胞菌为多重耐药菌 ,在耐三代头孢类抗生素的菌中有 77.4%的菌株产生超广谱 β 内酰胺酶 (ESBL) ,复方新诺明、多西环素是治疗嗜麦芽窄食单胞菌所致感染的较好药物。
Objective:In order to help clinicians understand the multiple resistance of S.maltophilia and choose antimicrobial agents correctly. Methods:Antimicrobial susceptibility test was performed by K B method; Extended spectrumβ lactamases were detected by double disk diffusion method. Results:S.maltophilia was resistant to most β lactam antimic robial agents, with resistance of almost 100% to penicillin, imipenem and cephalasporins. There were 77.4% strains producing extneded spectrum β lactamases among resistant S.maltophilia to the third generation cephalosporins. The activity of trimethoprim/sulfamethoxazole to S.maltophilia remained about 75% during the period of 1996～1998, doxycycline was another active drug to this kind of bacteria. Accordingly, these two antimicrobial agnets were the theropeutic drugs of the first choice to the infection caused by S.maltophilia. Conclusion:S.maltophilia is, due to its naturnal resistance to multiple drug, a clinically troublesome opportunistic species of nosocomial bacteria. Trimethoprim/sulfamethoxazole and doxycycline were the theropeutic drugs of the first choice to infection caused by S.maltophilia.
出处
《军医进修学院学报》
CAS
2000年第2期138-140,共3页
Academic Journal of Pla Postgraduate Medical School
