摘要
研究了用超临界 CO2 流体萃取法从黄花蒿中提取青蒿素的工艺 ,主要探讨了压力、时间、CO2 流量等因素对产品收率的影响 ,确定了最佳工艺条件 ,并进行了中试放大和工业化试验 ,所得产品质量达药品标准 ,与传统生产工艺 (如汽油法 )相比 ,收率提高了 1.9倍 ,生产周期缩短近 10 0 h,生产成本降低了 447元 /
A new technological process for extracting artemisinin from Artemisia annua L. by supercritical CO 2 fluid extraction (SFE CO 2) is described. The optimum technological conditions were as follows:extraction pressure 18 MPa, temperature 40℃; isolated pressure I 14 MPa, temperature 60℃; isolated pressure Ⅱ 6 MPa, temperature 50℃; CO 2 flow rate 10~20 kg/h·(kg crude herb); and extraction time 5 h. The new process is better than the conventional gasoline extraction in high yield, short time and low cost.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2000年第6期250-253,共4页
Chinese Journal of Pharmaceuticals
基金
国家"八五"科技攻关项目! ( 85- 11- 0 2 - 0 3和 85- 11- 0 2 - 0 8)
关键词
超临界CO2萃取
青蒿素
黄花蒿
supercritical-CO_2 fluid extraction
artemisinin
process
industrial-scale production
