摘要
目的 研究喹诺酮类药物的热稳定性及热降解 ,建立动力学方程。方法 用TG DTG热重仪测定药物的热解曲线 ,用Achar微分法和Coats Redfern积分法确定热分解函数。结果 根据TG DTG热解曲线和红外图谱推断出依诺沙星、诺氟沙星、盐酸芦氟沙星和氧氟沙星等 4种喹诺酮类药物的热分解过程并求出其热解动力学参数活化能E、反应级数n和指前因子A及动力学补偿参数。结论 热稳定性为盐酸芦氟沙星 >依诺沙星 >氧氟沙星>诺氟沙星 ,它们的热分解过程相同 ;4种药物胶囊的稳定性均大于各自原药 ;诺氟沙星、依诺沙星、氧氟沙星的热解机理函数相同 ,动力学方程为dα/dt=Ae-E/RT(1-α) 2 ,盐酸芦氟沙星为dα/dt=Ae-E/RT(1-α)
AIM To study the thermal stabilities of quinolone drugs and to establish equations for their decomposition kinetics. METHODS Using TG(thermogravimetry) DTG(differential thermogravimetry) to determine the thermal decomposition curves of the drugs and Achar differential method and Coats Redfern integral method to determine their thermal decomposition functions. RESULTS Form their TG DTG curves and IR spectra, the thermal decomposition processes of the four quinolone drugs were deduced and the thermal kinetic parameters, such as energy of activation ( E ), order of reaction ( n ), frequency factor ( A ) and kinetic compensation constants were determined. CONCLUSION The order of thermal stability is: rufloxacin hydrochloride > enoxacin > ofloxacin > norfloxacin, and the processes of thermal decomposition of the 4 drugs are the same. The thermal stabilities of the capsules of the 4 drugs are all better than the drug materials themselves. The mechanism functions of norfloxacin, enoxacin and ofloxacin are the same, the kinetic equation may be expressed as: dα/d t = A e - E/RT (1-α) 2, while for rufloxacin hydrochloride it is: dα/d t = A e - E/RT (1-α) 3.
出处
《药学学报》
CAS
CSCD
北大核心
2000年第6期445-450,共6页
Acta Pharmaceutica Sinica
关键词
热稳定性
非等温动力学
喹诺酮类药物
enoxacin
norfloxacin
rufloxacin hydrochoride
ofloxacin
thermogravimetry differential thermogravimetry
thermal stability
non isothermal kinetics
