摘要
目的探讨胃癌组织中表皮生长因子受体（EGFR）和蛋白激酶（AKT）表达情况与胃癌的临床病理特征相关性。方法用免疫组化的方法分别检测153例胃癌患者的癌组织和癌旁正常胃组织中EGFR、AKT的表达程度，分析其与患者临床病理特征的相关性。结果在不同的性别、年龄及不同肿瘤病理类型、分化程度的患者中，胃癌组织EGFR、AKT的表达程度比较差异无统计学意义（P〉0．05）。EGFR水平与TNM分期有关（X2=5．43，P〈0．05）；AKT的表达水平与肿瘤大小，T分期，TNM分期有关（x2=4．73、4．95、5．32，P〈0．05或P〈0．01）；出现淋巴结转移及远处转移的胃癌组织中AKT（X2=4．83、4．75，p〈0．05）、EGFR（X2=4．67，4．58，P〈0．05）表达水平分别较无转移者高。结论检测胃癌组织中EGFR、AKT的表达对于胃癌的诊断、疾病的分期和转移的判断有一定的参考意义。
Objective To explore the association between clinical pathological characteristics and the expressions of epidermal growth factor receptor （EGFR） and protein kinase B （AKT） in gastric carcinomas. Methods The expressions of EGFR and AKT were measured with immunohistochemical method in the cancer tissues and cancer-adjacent normal tissues from 153 cases of patients with gastric cancer. The association between clinical pathological characteristics and their expressions were analyzed. Results The expressions of AKT and EGFR in gastric cancer tissues had no relationship with gender, age, pathological type, and the degree of differentiation （ P 〉 0.05）. A positive correlation was existed between the EGFR and TNM stages （X2 = 5.43, P 〈 0. 05 ）. The AKT was positively related to the size, T stage, and TNM stage of the tumor, respectively （X2 = 4. 73, 4. 95,5.32, P 〈 0.05 or P 〈 0. 01 ）. The levels of AKT （X2 =4. 83,4. 75, P 〈 0. 05）and EGFR（ X2 = 4. 67,4. 58, P 〈 0. 05） in the gastric cancer tissues with lymph node and/or distant metastasis were significantly higher than the gastric cancer tissues without metastasis, respectively. Conclusions The over-expressions of AKT and EGFR would benefit the diagnosis and stages of a gastric cancer and the determination of its metastasis.
出处
《中国医师杂志》
CAS
2012年第11期1486-1489,共4页
Journal of Chinese Physician
关键词
受体
表皮生长因子
分析
蛋白激酶类
分析
胃肿瘤
病理学
Receptor, epidermal growth factor/analysis
Protein kinases/analysis
Stomach neo-plasms/pathology
