摘要
目的:检测肿瘤易感基因101(TSG101)及E钙黏蛋白(E-cadherin)在胃癌组织表达相关性及其与分化、转移等关系。方法:应用免疫组织化学方法检测TSG101及E-cadherin在81例胃癌及对应癌旁标本中表达情况,分析二者在胃癌组织表达相关性及其与患者分化、淋巴结转移等临床病理资料的关系。结果:TSG101在胃癌组织阳性表达率为67.9%(55/81),显著高于癌旁组织6.2%(5/81)(P<0.01);E-cadherin在胃癌阳性表达率为40.7%(33/81),显著低于癌旁组织96.3%(78/81)(P<0.01);TSG101与E-cadherin在胃癌组织表达水平与患者分化及淋巴结转移密切相关(P<0.05)。Pearson分析提示在胃癌组织中TSG101表达与E-cadherin表达呈负相关性(r=-0.775,P<0.01)。单因素分析显示,患者术后生存时间与TSG101、E-cadherin表达水平、TNM分期及淋巴结转移相关(P<0.05)。结论:TSG101与E-cadherin在胃癌组织中表达水平与胃癌分化、转移密切相关,两者表达呈负相关,对于胃癌患者生物治疗及评价预后有较好价值。
Objective：To investigate the relationships between TSG101 and E-cadherin co-expression in gastric cancer tissues,and analyze the associations with differentiation,lymph node metastasis and prognosis in gastric cancer patients.Methods： Immunohistochemical assay was used to detect the expression of TSG101 and E-cadherin in 81 primary gastric cancerous and matched non-cancerous tissues,and analyze the relationships between co-expression of TSG101 and E-cadherin correlated with clinical data including differentiation,lymph node metastasis and prognosis.Results： The positive rate of TSG101 in gastric cancer 67.9%（55/81） was significantly higher than matched non-cancerous tissues 6.2%（5/81）（P0.01）.The positive rate of E-cadherin in gastric cancer 40.7%（33/81） was significantly lower than matched non-cancerous tissues 96.3%（78/81）（P0.01）.Pearson analysis showed that TSG101 expression was significantly negatively correlated with E-cadherin in cancer tissues（r=-0.775,P0.01）.High TSG101 and low E-cadherin expression was correlated with differentiation and lymph node metastasis.Kaplan-Meier analysis showed that positive expression of TSG101 and negative expression of E-cadherin had lower survival rates compared to those with negative TSG101 and positive E-cadherin expression in gastric cancer patients（P0.05）.Conclusion： The positive TSG101 and negative E-cadherin expression were correlated with the differentiation,metastasis and poor prognosis of gastric cancer,indicating that TSG101 and E-cadherin might be critical for biotherapies and prognostic factors of gastric cancer.
出处
《现代肿瘤医学》
CAS
2012年第12期2591-2594,共4页
Journal of Modern Oncology
作者简介
艾小顺（1982-），男，江西新余人，医师，主要从事普外科肿瘤及急诊外科工作。E—mail：shun1209@126．com
