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腹腔镜下保守性手术联合术后辅助药物治疗中重度子宫内膜异位症56例临床疗效观察 被引量:6

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摘要 目的比较中重度子宫内膜异位症患者腹腔镜下保守性手术联合术后辅助促性腺激素释放激素激动剂(GnRH—a)皮下注射及口服短效避孕药2种治疗方法的临床疗效、不良反应、停药后复发率及对血清性激素水平影响。方法回顾性分析56例中重度子宫内膜异位症患者行腹腔镜下保守性手术,术后辅助药物治疗,GnRH—a组29例,避孕药组27例,观察各组治疗后的症状、体征缓解率、累积复发率、血清性激素水平变化和药物不良反应。结果GnRH-a组用药后其盆腔疼痛、痛经和性交痛等症状缓解率为93.1%(27,29),体征缓解率为86.2%(25,29),均高于避孕药组的74.1%(20/27)和66.7%(18,27),差异有统计学意义(P〈0.05);停药后1年累积复发率GnRH—a组6.9%(2/29),低于避孕药组的25.9%(7/27),差异有统计学意义(P〈0.05);GnRH—a组用药后6个月血清卯泡刺激素、黄体生成激素、雌二醇水平明显低于避孕药组[(2.18±1.03)U/L比(4.30±1.73)U/L、(2.36±1.78)U/L比(4.57±0.89)U/L、(36.90±1.37)pmol/L比(148.00±1.26)pmol/L],差异有统计学意义(P〈0.05)。结论与口服短效避孕药相比,腹腔镜下保守性手术术后联合应用GnRH.a可以提高中重度子宫内膜异位症患者的症状、体征缓解率及减少复发率,更好地改善中重度子宫内膜异位症患者的症状,从而提高患者的生活质量。
作者 韦宏力
出处 《中国医师进修杂志》 2012年第33期58-59,共2页 Chinese Journal of Postgraduates of Medicine
作者简介 韦宏力,Email:whlkuaile@163.com
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