摘要
目的探讨输卵管妊娠腹腔镜保守性手术联合药物预防持续性异位妊娠(PEP)的临床疗效。方法按入院的先后顺序,将110例输卵管妊娠患者随机分为观察组与对照组,每组55例。对照组仅行单纯腹腔镜保守性手术;观察组腹腔镜保守性手术前口服米非司酮,术后应用米非司酮联合甲氨蝶呤治疗。检测术后1、3、7、12d血β-hCG水平,并进行比较。结果两组术后3、7、12d的血β-hCG水平,组间比较差异有统计学意义(P<0.05)。观察组无PEP发生,对照组有4例(7.3%,4/55)发生PEP,组间比较差异有统计学意义(P<0.05)。结论输卵管妊娠腹腔镜保守性手术联合药物预防PEP,血β-hCG水平下降快,PEP发生率低,优于单独腹腔镜保守性手术治疗,值得临床推广应用。
Objective To explore the clinical efficacy of tubal pregnancy Laparoscopic conservative surgery combined with drugs to prevent persistent ectopic pregnancy （PEP）. Methods According to the order of admission, 110 cases of tubal pregnancy were randomly divided into observation and control group （n = 55）. The control group only underwent laparoscopic conservative surgery alone; the observa- tion group Laparoscopic conservative surgery before oral mifepristone after mifepristone combined with methotrexate therapy. Detect postoperative 1,3,7,12d blood β- hCG level and compare. Results The postoperative 3,7,12 d serum β-hCG level, the difference between groups was statistically significant （P 〈 0.05）. PEP occurred in the observation group and the control group, 4 patients （7.3% ,4/55） occurred the PEP, the difference between groups was statistically significant （P〈0.05）. Conclusions Tubal pregnancy laparoscopic conservative surgery combined with drug prevention the PEP blood β- hCG level dropped fast, the PEP low incidence, is superior to laparoscopic conservative surgical treatment worthy of clinical application.
出处
《齐齐哈尔医学院学报》
2012年第21期2887-2888,共2页
Journal of Qiqihar Medical University
关键词
输卵管妊娠
腹腔镜保守性手术
氨甲喋呤
米非司酮
持续性异位妊娠
Tubal pregnancy
Laparoscopic conservative surgery
Methotrexate
Mifepristone
Persistent ectopic pregnance
